E J McIntee
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Explore the profile of E J McIntee including associated specialties, affiliations and a list of published articles.
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18
Citations
305
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Recent Articles
1.
Hecht S, McIntee E, Cheng G, Shi Y, Villalta P, Wang M
Adv Exp Med Biol
. 2002 Jan;
500:63-71.
PMID: 11765008
No abstract available.
2.
Wang M, McIntee E, Shi Y, Cheng G, Upadhyaya P, Villalta P, et al.
Chem Res Toxicol
. 2001 Oct;
14(10):1435-45.
PMID: 11599936
We investigated the reactions of alpha-acetoxy-N-nitrosopyrrolidine (alpha-acetoxyNPYR) with dGuo and DNA. Alpha-acetoxyNPYR is a stable precursor to the major proximate carcinogen of NPYR, alpha-hydroxyNPYR (3). Our goal was to develop...
3.
McIntee E, Wagner C
Bioorg Med Chem Lett
. 2001 Oct;
11(21):2803-5.
PMID: 11597404
A series of aromatic, serum-stable, water soluble and nontoxic amino acid phosphoramidate monoesters of 5-fluoro-2'-deoxyuridine (FUdR) and 1-beta-arabinofuranosylcytosine (Ara-C) was shown to inhibit the cellular growth of the human leukemia...
4.
Hecht S, McIntee E, Wang M
Toxicology
. 2001 Aug;
166(1-2):31-6.
PMID: 11518608
This paper summarizes our recent studies on adducts produced in the reactions of the carcinogens crotonaldehyde (2-butenal) and acetaldehyde with deoxyguanosine (dG) and DNA. Human exposure to these carcinogens can...
5.
Wang M, McIntee E, Cheng G, Shi Y, Villalta P, Hecht S
Chem Res Toxicol
. 2001 Aug;
14(8):1025-32.
PMID: 11511176
In a recent study, we identified several new DNA adducts of the carcinogen acetaldehyde, including N(2)-(2,6-dimethyl-1,3-dioxan-4-yl)deoxyguanosine (N(2)-aldoxane-dG, 2). Our goal in this study was to investigate further the formation of...
6.
Upadhyaya P, McIntee E, Hecht S
Chem Res Toxicol
. 2001 May;
14(5):555-61.
PMID: 11368554
Nicotine and cotinine are metabolized to pyridine-N-glucuronides in humans. This suggests that the analogous metabolites of the carcinogenic nicotine-related nitrosamines N'-nitrosonornicotine (NNN), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) should also be...
7.
Wang M, McIntee E, Cheng G, Shi Y, Villalta P, Hecht S
Chem Res Toxicol
. 2001 Apr;
14(4):423-30.
PMID: 11304131
Previous studies have demonstrated that the reaction of crotonaldehyde with DNA produces Michael addition products, and these have been detected in human tissues as well as tissues of untreated laboratory...
8.
Wang M, McIntee E, Cheng G, Shi Y, Villalta P, Hecht S
Chem Res Toxicol
. 2000 Nov;
13(11):1149-57.
PMID: 11087437
Acetaldehyde is a mutagen and carcinogen which occurs widely in the human environment, sometimes in considerable amounts, but little is known about its reactions with DNA. In this study, we...
9.
Wang M, McIntee E, Cheng G, Shi Y, Villalta P, Hecht S
Chem Res Toxicol
. 2000 Nov;
13(10):1065-74.
PMID: 11080056
Crotonaldehyde (1) is a mutagen and carcinogen, but its reactions with DNA have been only partially characterized. In a previous study, we found that substantial amounts of 2-(2-hydroxypropyl)-4-hydroxy-6-methyl-1,3-dioxane (paraldol, 7),...
10.
Wagner C, Iyer V, McIntee E
Med Res Rev
. 2000 Nov;
20(6):417-51.
PMID: 11058891
To overcome the many hurdles preventing the use of antiviral and anticancer nucleosides as therapeutics, the development of a prodrug methodology (i.e., pronucleotide) for the in vivo delivery of nucleotides...