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E J Gubbins

Explore the profile of E J Gubbins including associated specialties, affiliations and a list of published articles. Areas
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Articles 15
Citations 241
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Recent Articles
1.
Larrinua I, Muskavitch K, Gubbins E, Bogorad L
Plant Mol Biol . 2013 Dec; 2(3):129-40. PMID: 24318207
Fragments produced by partial digestion of plastid DNA fromZea mays withEco RI were cloned in Charon 4A. A circular, fine structure physical map of the plastid DNA was then constructed...
2.
Briggs C, Schrimpf M, Anderson D, Gubbins E, Gronlien J, Hakerud M, et al.
Br J Pharmacol . 2007 Dec; 153(5):1054-61. PMID: 18157163
Background And Purpose: The alpha7 nicotinic acetylcholine receptor (nAChR) has attracted considerable interest as a target for cognitive enhancement in schizophrenia and Alzheimer's Disease. However, most recently described alpha7 agonists...
3.
Trevillyan J, Chiou X, Chen Y, Ballaron S, Sheets M, Smith M, et al.
J Biol Chem . 2001 Oct; 276(51):48118-26. PMID: 11592964
NFAT (nuclear factor of activated T cell) proteins are expressed in most immune system cells and regulate the transcription of cytokine genes critical for the immune response. The activity of...
4.
Luo Y, Joseph M, Bradner J, Butler C, Tahir S, Han E, et al.
Anticancer Res . 2001 Apr; 21(1A):23-8. PMID: 11299740
Background: Chkl is a checkpoint gene that is activated after DNA damage. It phosphorylates and inactivates Cdc25C at the late G2 phase. The inactivation of Cdc25C and consequently, the inactivation...
5.
Trevillyan J, Chiou X, Ballaron S, Tang Q, Buko A, Sheets M, et al.
Arch Biochem Biophys . 1999 Mar; 364(1):19-29. PMID: 10087161
Lck encodes a 56-kDa protein-tyrosine kinase, predominantly expressed in T lymphocytes, crucial for initiating T cell antigen receptor (TCR) signal transduction pathways, culminating in T cell cytokine gene expression and...
6.
Holzman T, Chung C, Edalji R, Egan D, Martin M, Gubbins E, et al.
J Protein Chem . 1991 Oct; 10(5):553-63. PMID: 1799412
The kinetic behavior and pH-stability of recombinant human renin was analyzed using a new fluorogenic substrate based on the normal P6-P3' renin cleavage sequence in human angiotensinogen. The design of...
7.
Edalji R, Holzman T, Gubbins E
J Protein Chem . 1991 Aug; 10(4):403-6. PMID: 1781885
Using highly purified recombinant human prorenin, we report the first evidence for the formation of a stable, partially active, conformational variant of the recombinant proenzyme. The enzymatically active prorenin exhibits...
8.
Holzman T, Chung C, Edalji R, Egan D, Gubbins E, Rueter A, et al.
J Protein Chem . 1990 Dec; 9(6):663-72. PMID: 1963533
The gene for human preprorenin was obtained from total RNA prepared from primary human chorion cells. An expression vector was constructed containing an SV40 early promoter, a human preprorenin cDNA,...
9.
Steinmetz A, Krebbers E, Schwarz Z, Gubbins E, Bogorad L
J Biol Chem . 1983 May; 258(9):5503-11. PMID: 6853530
Maize chloroplast tRNA genes encoding tRNA3Ser, tRNAPhe, tRNA2Thr, tRNA2Leu, and tRNAmMet, and their flanking regions have been sequenced. All five gene sequences show features commonly found in the few chloroplast...
10.
Steinmetz A, Gubbins E, Bogorad L
Nucleic Acids Res . 1982 May; 10(10):3027-37. PMID: 6285285
The maize chloroplast gene encoding tRNA Leu UAA has been sequenced. It contains a 458 base pair intron between the first and second bases of the anticodon. The tRNA is...