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M P Sheets

Explore the profile of M P Sheets including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 70
Followers 0
Related Specialties
Biochemistry
Dermatology
Chemistry
Top 10 Co-Authors
K W Mollison
J M Trevillyan
M L Smith
Y W Chen
J R Luly
K Marsh
G C Hsieh
M Pong
D M Gauvin
S J Ballaron
Published In
Bioorg Med Chem Lett
Curr Pharm Des
J Biol Chem
Clin Immunol
J Invest Dermatol
Affiliations
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Recent Articles
1.
Potent inhibition of NFAT activation and T cell cytokine production by novel low molecular weight pyrazole compounds
Trevillyan J, Chiou X, Chen Y, Ballaron S, Sheets M, Smith M, et al.
J Biol Chem . 2001 Oct; 276(51):48118-26. PMID: 11592964
NFAT (nuclear factor of activated T cell) proteins are expressed in most immune system cells and regulate the transcription of cytokine genes critical for the immune response. The activity of...
2.
3,5-Bis(trifluoromethyl)pyrazoles: a novel class of NFAT transcription factor regulator
Djuric S, BaMaung N, Basha A, Liu H, Luly J, Madar D, et al.
J Med Chem . 2000 Aug; 43(16):2975-81. PMID: 10956206
A series of bis(trifluoromethyl)pyrazoles (BTPs) has been found to be a novel inhibitor of cytokine production. Identified initially as inhibitors of IL-2 synthesis, the BTPs have been optimized in this...
3.
A macrolactam inhibitor of T helper type 1 and T helper type 2 cytokine biosynthesis for topical treatment of inflammatory skin diseases
Mollison K, Fey T, Gauvin D, Kolano R, Sheets M, Smith M, et al.
J Invest Dermatol . 1999 May; 112(5):729-38. PMID: 10233764
T lymphocytes play a critical part in inflammatory skin diseases but are targeted by available therapies that have only partial efficacy, significant side-effects, or both. Because psoriasis, atopic dermatitis, and...
4.
Discovery of ascomycin analogs with potent topical but weak systemic activity for treatment of inflammatory skin diseases
Mollison K, Fey T, Gauvin D, Sheets M, Smith M, Pong M, et al.
Curr Pharm Des . 1999 Apr; 4(5):367-79. PMID: 10197049
Drug therapy for the major inflammatory skin diseases, which include atopic dermatitis, psoriasis and allergic contact dermatitis, is often inadequate due to poor efficacy, toxicity, or both. Much research has...
5.
Inhibition of p56(lck) tyrosine kinase by isothiazolones
Trevillyan J, Chiou X, Ballaron S, Tang Q, Buko A, Sheets M, et al.
Arch Biochem Biophys . 1999 Mar; 364(1):19-29. PMID: 10087161
Lck encodes a 56-kDa protein-tyrosine kinase, predominantly expressed in T lymphocytes, crucial for initiating T cell antigen receptor (TCR) signal transduction pathways, culminating in T cell cytokine gene expression and...
6.
Ex vivo assessment of immunosuppression in undiluted whole blood from pigs dosed with tacrolimus (FK506)
Chen Y, Smith M, Sheets M, Ballaron S, Trevillyan J, Fey T, et al.
Clin Immunol . 1999 Jan; 90(1):133-40. PMID: 9884362
To assess the duration of immunosuppression in FK506-dosed pigs, an undiluted whole blood assay was established to measure reactivities of T cells in their physiological milieu. PMA and ionomycin were...
7.
Synthesis and immunosuppressant activity of pyrazole carboxamides
Wang A, Xie Q, Lane B, Mollison K, Hsieh G, Marsh K, et al.
Bioorg Med Chem Lett . 1999 Jan; 8(19):2787-92. PMID: 9873623
A series of novel pyrazole carboxamides is disclosed that demonstrate strong immunosuppressant activity in rodent and human mixed leukocyte response (MLR) assays (IC50 < 1 microM). The synthesis, biological activity,...