E D Tomhave
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Explore the profile of E D Tomhave including associated specialties, affiliations and a list of published articles.
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353
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Recent Articles
1.
Iaccarino G, Tomhave E, Lefkowitz R, Koch W
Circulation
. 1998 Oct;
98(17):1783-9.
PMID: 9788834
Background: Impaired myocardial beta-adrenergic receptor (betaAR) signaling, including desensitization and functional uncoupling, is a characteristic of congestive heart failure. A contributing mechanism for this impairment may involve enhanced myocardial beta-adrenergic...
2.
Iaccarino G, Rockman H, Shotwell K, Tomhave E, Koch W
Am J Physiol
. 1998 Sep;
275(4):H1298-306.
PMID: 9746479
Transgenic mice were generated with cardiac-specific overexpression of the G protein-coupled receptor kinase 3 (GRK3) to explore the in vivo role of this GRK in cardiac function. GRK3 is expressed...
3.
Xiao R, Tomhave E, Wang D, Ji X, Boluyt M, Cheng H, et al.
J Clin Invest
. 1998 Apr;
101(6):1273-82.
PMID: 9502768
While an age-associated diminution in myocardial contractile response to beta-adrenergic receptor (beta-AR) stimulation has been widely demonstrated to occur in the context of increased levels of plasma catecholamines, some critical...
4.
Ali H, Tomhave E, Richardson R, Haribabu B, Snyderman R
J Biol Chem
. 1996 Feb;
271(6):3200-6.
PMID: 8621721
To define the molecular basis of human chemoattractant receptor regulation, rat basophilic leukemia RBL-2H3 cells, which are thrombin-responsive, were transfected to stably express epitope-tagged receptors for C5a, interleukin-8 (IL-8), formylpeptides...
5.
Richardson R, Ali H, Tomhave E, Haribabu B, Snyderman R
J Biol Chem
. 1995 Nov;
270(46):27829-33.
PMID: 7499254
To define the molecular mechanisms of cross-regulation among chemoattractant receptors, we stably coexpressed, in a rat basophilic leukemia (RBL-2H3) cell line, epitope-tagged receptors for the chemoattractants formylmethionylleucylphenylalanine (fMLP), a peptide...
6.
Richardson R, DuBose R, Ali H, Tomhave E, Haribabu B, Snyderman R
Biochemistry
. 1995 Oct;
34(43):14193-201.
PMID: 7578017
The human type A interleukin-8 receptor (IL-8RA) was modified to express an amino-terminal epitope tag and stably overexpressed in a rat basophilic leukemia cell line (RBL-2H3). This receptor (ET-IL-8RA) displayed...
7.
Haribabu B, Hook S, Selbert M, Goldstein E, Tomhave E, EDELMAN A, et al.
EMBO J
. 1995 Aug;
14(15):3679-86.
PMID: 7641687
Human Ca(2+)-calmodulin (CaM) dependent protein kinase I (CaMKI) encodes a 370 amino acid protein with a calculated M(r) of 41,337. The 1.5 kb CaMKI mRNA is expressed in many different...
8.
Ali H, Richardson R, Tomhave E, DuBose R, Haribabu B, Snyderman R
J Biol Chem
. 1994 Oct;
269(40):24557-63.
PMID: 7929127
Platelet activating factor (PAF) interacts with cell surface receptors to mediate inflammatory responses. To determine the mechanisms of PAF receptor regulation, we constructed epitope-tagged human PAF receptor cDNA (ET-PAFR) and...
9.
Tomhave E, Richardson R, Didsbury J, Menard L, Snyderman R, Ali H
J Immunol
. 1994 Oct;
153(7):3267-75.
PMID: 8089498
The formylpeptide (fMLP) and C5a chemoattractants were previously shown to cross-desensitize each other's ability to mobilize Ca2+ in leukocytes but not to affect nonchemoattractant Ca(2+)-mobilizing receptors, and vice versa. Our...
10.
Ali H, Richardson R, Tomhave E, Didsbury J, Snyderman R
J Biol Chem
. 1993 Nov;
268(32):24247-54.
PMID: 8226971
To define the regulation of chemoattractant receptors, epitope-tagged human formyl peptide and C5a receptor cDNAs (ET-FR and ET-C5aR) were stably expressed in rat basophilic leukemia, RBL-2H3 cells. An antibody (12CA5)...