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E D Brown

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Articles 85
Citations 1967
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Recent Articles
1.
McAuley S, Huynh A, Czarny T, Brown E, Nodwell J
Medchemcomm . 2018 Aug; 9(3):554-561. PMID: 30108946
Small molecule disruption of the bacterial membrane is both a challenge and interest for drug development. While some avoid membrane activity due to toxicity issues, others are interested in leveraging...
2.
Czarny T, Perri A, French S, Brown E
Antimicrob Agents Chemother . 2014 Apr; 58(6):3261-9. PMID: 24687489
The emergence of antibiotic resistance in recent years has radically reduced the clinical efficacy of many antibacterial treatments and now poses a significant threat to public health. One of the...
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Sollmann T, Brown E
J Exp Med . 2009 Oct; 6(3):207-56. PMID: 19866971
THE CONCLUSIONS WHICH WE DERIVE FROM OUR OBSERVATIONS ARE AS FOLLOWS: 1. The excretion of injected, egg-albumen as such is in no case complete. The quantity retained varies from 23...
5.
Laufer E, Hartman T, Baer D, Gunter E, Dorgan J, Campbell W, et al.
Eur J Clin Nutr . 2004 May; 58(11):1518-24. PMID: 15138463
Background: Although alcohol intake has been positively associated with breast cancer risk in epidemiologic studies, a causal relationship has not been established, and the mechanisms mediating this association are speculative....
6.
Bhavsar A, Beveridge T, Brown E
J Bacteriol . 2001 Oct; 183(22):6688-93. PMID: 11673441
Using a previously reported conditional expression system for use in Bacillus subtilis (A. P. Bhavsar, X. Zhao, and E. D. Brown, Appl. Environ. Microbiol. 67:403-410, 2001), we report the first...
7.
Yim V, Zolli M, Badurina D, Rossi L, Brown E, Berghuis A
Acta Crystallogr D Biol Crystallogr . 2001 May; 57(Pt 6):918-20. PMID: 11375529
Glycerol 3-phosphate cytidylyltransferase from Staphylococcus aureus (TarD(Sa)) has been expressed in Escherichia coli, purified to homogeneity and crystallized. The strategy used for determining crystallization conditions employed hanging-drop sparse-matrix screens and...
8.
Dorgan J, Baer D, Albert P, Judd J, Brown E, Corle D, et al.
J Natl Cancer Inst . 2001 May; 93(9):710-5. PMID: 11333294
Background: Alcohol ingestion is associated with an increased risk of breast cancer in most epidemiologic studies. Results, however, are heterogeneous at lower levels of alcohol intake, and a biologic mechanism...
9.
Zolli M, Kobric D, Brown E
Biochemistry . 2001 Apr; 40(16):5041-8. PMID: 11305920
CDP-ribitol synthase is a bifunctional reductase and cytidylyltransferase that catalyzes the transformation of D-ribulose 5-phosphate, NADPH, and CTP to CDP-ribitol, a repeating unit present in the virulence-associated polysaccharide capsules of...
10.
Bhavsar A, Zhao X, Brown E
Appl Environ Microbiol . 2001 Jan; 67(1):403-10. PMID: 11133472
We have developed a xylose-dependent expression system for tight and modulated expression of cloned genes in Bacillus subtilis. The expression system is contained on plasmid pSWEET for integration at the...