Dyann M Segvich
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Explore the profile of Dyann M Segvich including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
365
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Recent Articles
1.
Reul O, Surowiec R, Chowdhury N, Segvich D, Wallace J
J Mech Behav Biomed Mater
. 2025 Feb;
165:106950.
PMID: 39961220
The use of compressive axial tibial loading for evaluation of bone adaptation and mechanotransduction has become a common technique in recent years. Despite its popularity, it only produces a single...
2.
Kohler R, Segvich D, Reul O, Metzger C, Allen M, Wallace J
Bone
. 2025 Jan;
194:117415.
PMID: 39884489
Comorbid diabetes and chronic kidney disease create a complex disease state with multi-faceted impacts on bone health, primarily reduced bone mass and tissue quality. To reduce fracture risk in this...
3.
Ramirez G, Okpara C, Arnett M, Segvich D, Deosthale P, Gonzalez P, et al.
J Bone Miner Res
. 2024 Sep;
39(11):1659-1672.
PMID: 39255371
Vertebrate sexual dimorphism is ascribed to the presence of testes or ovaries, and, hence, to the secretion of gonad-specific hormones. However, mounting evidence indicates that sex differences in tissues and...
4.
Kohler R, Segvich D, Reul O, Metzger C, Allen M, Wallace J
Bone Rep
. 2024 May;
21:101774.
PMID: 38778834
As international incidence of diabetes and diabetes-driven comorbidities such as chronic kidney disease (CKD) continue to climb, interventions are needed that address the high-risk skeletal fragility of what is a...
5.
Chowdhury N, Surowiec R, Kohler R, Reul O, Segvich D, Wallace J
Calcif Tissue Int
. 2024 Apr;
114(6):638-649.
PMID: 38642089
Type 2 diabetes (T2D) increases fracture incidence and fracture-related mortality rates (KK.Cg-Ay/J. The Jackson Laboratory; Available from: https://www.jax.org/strain/002468 ). While numerous mouse models for T2D exist, few effectively stimulate persistent...
6.
Skurat A, Segvich D, Contreras C, Hu Y, Hurley T, DePaoli-Roach A, et al.
J Biol Chem
. 2024 Apr;
300(5):107271.
PMID: 38588813
Lafora disease (LD) is an autosomal recessive myoclonus epilepsy with onset in the teenage years leading to death within a decade of onset. LD is characterized by the overaccumulation of...
7.
Reul O, Anneken A, Kohler R, Segvich D, Wallace J
J Vis Exp
. 2023 Sep;
(199).
PMID: 37677027
Skeletal fragility leading to fracture is an American public health crisis resulting in 1.5 million fractures each year and $18 billion in direct care costs. The ability to understand the...
8.
Hatch J, Segvich D, Kohler R, Wallace J
Bone Rep
. 2022 Aug;
17:101609.
PMID: 35941910
Diabetes Mellitus is a metabolic disease which profoundly affects many organ systems in the body, including the skeleton. As is often the case with biology, there are inherent differences between...
9.
Sun R, Young L, Bruntz R, Markussen K, Zhou Z, Conroy L, et al.
Cell Metab
. 2021 May;
33(7):1404-1417.e9.
PMID: 34043942
Glycosylation defects are a hallmark of many nervous system diseases. However, the molecular and metabolic basis for this pathology is not fully understood. In this study, we found that N-linked...
10.
Tang B, Frasinyuk M, Chikwana V, Mahalingan K, Morgan C, Segvich D, et al.
J Med Chem
. 2020 Mar;
63(7):3538-3551.
PMID: 32134266
The overaccumulation of glycogen appears as a hallmark in various glycogen storage diseases (GSDs), including Pompe, Cori, Andersen, and Lafora disease. Accumulating evidence suggests that suppression of glycogen accumulation represents...