Christopher J Contreras
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Explore the profile of Christopher J Contreras including associated specialties, affiliations and a list of published articles.
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12
Citations
206
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Recent Articles
1.
Colglazier K, Mukherjee N, Contreras C, Templin A
J Endocrinol
. 2024 Jun;
262(2).
PMID: 38842911
β-Cell death contributes to β-cell loss and insulin insufficiency in type 1 diabetes (T1D), and this β-cell demise has been attributed to apoptosis and necrosis. Apoptosis has been viewed as...
2.
Skurat A, Segvich D, Contreras C, Hu Y, Hurley T, DePaoli-Roach A, et al.
J Biol Chem
. 2024 Apr;
300(5):107271.
PMID: 38588813
Lafora disease (LD) is an autosomal recessive myoclonus epilepsy with onset in the teenage years leading to death within a decade of onset. LD is characterized by the overaccumulation of...
3.
Mukherjee N, Contreras C, Lin L, Colglazier K, Mather E, Kalwat M, et al.
Mol Metab
. 2024 Jan;
80:101877.
PMID: 38218538
Objective: Aggregation of human islet amyloid polypeptide (hIAPP), a β-cell secretory product, leads to islet amyloid deposition, islet inflammation and β-cell loss in type 2 diabetes (T2D), but the mechanisms...
4.
Contreras C, Mukherjee N, Branco R, Lin L, Hogan M, Cai E, et al.
Mol Metab
. 2022 Aug;
65:101582.
PMID: 36030035
Objective: Type 1 diabetes (T1D) is characterized by autoimmune-associated β-cell loss, insulin insufficiency, and hyperglycemia. Although TNFα signaling is associated with β-cell loss and hyperglycemia in non-obese diabetic mice and...
5.
Mukherjee N, Lin L, Contreras C, Templin A
Metabolites
. 2021 Nov;
11(11).
PMID: 34822454
β-cell death is regarded as a major event driving loss of insulin secretion and hyperglycemia in both type 1 and type 2 diabetes mellitus. In this review, we explore past,...
6.
Sun R, Young L, Bruntz R, Markussen K, Zhou Z, Conroy L, et al.
Cell Metab
. 2021 May;
33(7):1404-1417.e9.
PMID: 34043942
Glycosylation defects are a hallmark of many nervous system diseases. However, the molecular and metabolic basis for this pathology is not fully understood. In this study, we found that N-linked...
7.
Young L, Brizzee C, Macedo J, Murphy R, Contreras C, DePaoli-Roach A, et al.
Carbohydr Polym
. 2020 Jan;
230:115651.
PMID: 31887930
The addition of phosphate groups into glycogen modulates its branching pattern and solubility which all impact its accessibility to glycogen interacting enzymes. As glycogen architecture modulates its metabolism, it is...
8.
Contreras C, Segvich D, Mahalingan K, Chikwana V, Kirley T, Hurley T, et al.
Arch Biochem Biophys
. 2016 Apr;
597:21-9.
PMID: 27036853
The storage polymer glycogen normally contains small amounts of covalently attached phosphate as phosphomonoesters at C2, C3 and C6 atoms of glucose residues. In the absence of the laforin phosphatase,...
9.
DePaoli-Roach A, Contreras C, Segvich D, Heiss C, Ishihara M, Azadi P, et al.
J Biol Chem
. 2014 Nov;
290(2):841-50.
PMID: 25416783
Glycogen is a branched polymer of glucose that acts as an energy reserve in many cell types. Glycogen contains trace amounts of covalent phosphate, in the range of 1 phosphate...
10.
Chikwana V, Khanna M, Baskaran S, Tagliabracci V, Contreras C, DePaoli-Roach A, et al.
Proc Natl Acad Sci U S A
. 2013 Dec;
110(52):20976-81.
PMID: 24324135
Glycogen is a glucose polymer that contains minor amounts of covalently attached phosphate. Hyperphosphorylation is deleterious to glycogen structure and can lead to Lafora disease. Recently, it was demonstrated that...