Duilio Cascio
Overview
Explore the profile of Duilio Cascio including associated specialties, affiliations and a list of published articles.
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Articles
144
Citations
6800
Followers
0
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Recent Articles
11.
Macdonald R, Mahoney B, Soule J, Goring A, Ford J, Loo J, et al.
Proc Natl Acad Sci U S A
. 2023 Jan;
120(5):e2211939120.
PMID: 36693107
(group A ) is a clinically important microbial pathogen that requires iron in order to proliferate. During infections, uses the surface displayed Shr receptor to capture human hemoglobin (Hb) and...
12.
Bowler J, Sawaya M, Boyer D, Cascio D, Bali M, Eisenberg D
J Biol Chem
. 2022 Aug;
298(10):102396.
PMID: 35988647
Amyloid protein aggregation is commonly associated with progressive neurodegenerative diseases, however not all amyloid fibrils are pathogenic. The neuronal cytoplasmic polyadenylation element binding protein is a regulator of synaptic mRNA...
13.
Tetreau G, Sawaya M, De Zitter E, Andreeva E, Banneville A, Schibrowsky N, et al.
Nat Commun
. 2022 Jul;
13(1):4376.
PMID: 35902572
Cry11Aa and Cry11Ba are the two most potent toxins produced by mosquitocidal Bacillus thuringiensis subsp. israelensis and jegathesan, respectively. The toxins naturally crystallize within the host; however, the crystals are...
14.
Aoki M, Vinokur J, Motoyama K, Ishikawa R, Collazo M, Cascio D, et al.
J Biol Chem
. 2022 Jun;
298(7):102111.
PMID: 35690147
Mevalonate 3,5-bisphosphate decarboxylase is involved in the recently discovered Thermoplasma-type mevalonate pathway. The enzyme catalyzes the elimination of the 3-phosphate group from mevalonate 3,5-bisphosphate as well as concomitant decarboxylation of...
15.
Abskharon R, Sawaya M, Boyer D, Cao Q, Nguyen B, Cascio D, et al.
Proc Natl Acad Sci U S A
. 2022 Apr;
119(15):e2119952119.
PMID: 35377792
In neurodegenerative diseases including Alzheimer’s and amyotrophic lateral sclerosis, proteins that bind RNA are found in aggregated forms in autopsied brains. Evidence suggests that RNA aids nucleation of these pathological...
16.
Mahoney B, Takayesu A, Zhou A, Cascio D, Clubb R
Proteins
. 2022 Feb;
90(7):1457-1467.
PMID: 35194841
Clostridium thermocellum is actively being developed as a microbial platform to produce biofuels and chemicals from renewable plant biomass. An attractive feature of this bacterium is its ability to efficiently...
17.
Martinez O, Mahoney B, Goring A, Yi S, Tran D, Cascio D, et al.
J Biol Chem
. 2021 Dec;
298(2):101464.
PMID: 34864059
Wall teichoic acid (WTA) polymers are covalently affixed to the Gram-positive bacterial cell wall and have important functions in cell elongation, cell morphology, biofilm formation, and β-lactam antibiotic resistance. The...
18.
Kim L, Ohashi M, Zhang Z, Tan D, Asay M, Cascio D, et al.
Nat Chem Biol
. 2021 Jul;
17(8):872-877.
PMID: 34312563
More than 60% of pharmaceuticals are related to natural products (NPs), chemicals produced by living organisms. Despite this, the rate of NP discovery has slowed over the past few decades....
19.
Vadivel K, Schmidt A, Cascio D, Padmanabhan K, Krishnaswamy S, Brandstetter H, et al.
Acta Crystallogr D Struct Biol
. 2021 Jun;
77(Pt 6):809-819.
PMID: 34076594
Coagulation factor VIIa (FVIIa) consists of a γ-carboxyglutamic acid (GLA) domain, two epidermal growth factor-like (EGF) domains and a protease domain. FVIIa binds three Mg ions and four Ca ions...
20.
Tayeb-Fligelman E, Cheng X, Tai C, Bowler J, Griner S, Sawaya M, et al.
bioRxiv
. 2021 Mar;
PMID: 33688654
One Sentence Summary: Atomic structures of amyloid-driving peptide segments from SARS-CoV-2 Nucleoprotein inform the development of Covid-19 therapeutics.