David S Eisenberg
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Explore the profile of David S Eisenberg including associated specialties, affiliations and a list of published articles.
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91
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Recent Articles
1.
Buxbaum J, Eisenberg D, Fandrich M, McPhail E, Merlini G, Saraiva M, et al.
Amyloid
. 2024 Oct;
31(4):249-256.
PMID: 39350582
The ISA Nomenclature Committee met at the XIX International Symposium of Amyloidosis in Rochester, MN, 27 May 2024. The in-person event was followed by many electronic discussions, resulting in the...
2.
Hou K, Pan H, Shahpasand-Kroner H, Hu C, Abskharon R, Seidler P, et al.
Sci Adv
. 2024 May;
10(18):eadl2991.
PMID: 38691615
Amyloid fibrils of tau are increasingly accepted as a cause of neuronal death and brain atrophy in Alzheimer's disease (AD). Diminishing tau aggregation is a promising strategy in the search...
3.
Hou K, Ge P, Sawaya M, Dolinsky J, Yang Y, Jiang Y, et al.
bioRxiv
. 2024 Apr;
PMID: 38585812
Reducing fibrous aggregates of protein tau is a possible strategy for halting progression of Alzheimer's disease (AD). Previously we found that the D-peptide D-TLKIVWC disassembles tau fibrils from AD brains...
4.
Nguyen B, Singh V, Afrin S, Yakubovska A, Wang L, Ahmed Y, et al.
Nat Commun
. 2024 Jan;
15(1):581.
PMID: 38233397
ATTR amyloidosis is caused by the deposition of transthyretin in the form of amyloid fibrils in virtually every organ of the body, including the heart. This systemic deposition leads to...
5.
Rosenberg G, Abskharon R, Boyer D, Ge P, Sawaya M, Eisenberg D
PNAS Nexus
. 2023 Dec;
2(12):pgad402.
PMID: 38077690
We previously presented a bioinformatic method for identifying diseases that arise from a mutation in a protein's low-complexity domain that drives the protein into pathogenic amyloid fibrils. One protein so...
6.
Lu J, Ge P, Sawaya M, Hughes M, Boyer D, Cao Q, et al.
J Biol Chem
. 2023 Dec;
300(2):105531.
PMID: 38072051
Heterogeneous nuclear ribonucleoprotein A2 (hnRNPA2) is a human ribonucleoprotein that transports RNA to designated locations for translation via its ability to phase separate. Its mutated form, D290V, is implicated in...
7.
Abskharon R, Pan H, Sawaya M, Seidler P, Olivares E, Chen Y, et al.
Proc Natl Acad Sci U S A
. 2023 Oct;
120(41):e2300258120.
PMID: 37801475
Despite much effort, antibody therapies for Alzheimer's disease (AD) have shown limited efficacy. Challenges to the rational design of effective antibodies include the difficulty of achieving specific affinity to critical...
8.
Tayeb-Fligelman E, Bowler J, Tai C, Sawaya M, Jiang Y, Garcia Jr G, et al.
Nat Commun
. 2023 May;
14(1):2379.
PMID: 37185252
The self-assembly of the Nucleocapsid protein (NCAP) of SARS-CoV-2 is crucial for its function. Computational analysis of the amino acid sequence of NCAP reveals low-complexity domains (LCDs) akin to LCDs...
9.
Murray K, Hu C, Pan H, Lu J, Abskharon R, Bowler J, et al.
Proc Natl Acad Sci U S A
. 2023 Feb;
120(7):e2217835120.
PMID: 36757890
The amyloid aggregation of alpha-synuclein within the brain is associated with the pathogenesis of Parkinson's disease (PD) and other related synucleinopathies, including multiple system atrophy (MSA). Alpha-synuclein aggregates are a...
10.
Buxbaum J, Dispenzieri A, Eisenberg D, Fandrich M, Merlini G, Saraiva M, et al.
Amyloid
. 2022 Nov;
29(4):213-219.
PMID: 36420821
The Nomenclature Committee of the International Society of Amyloidosis met at the XVIII International Symposium on Amyloidosis in September and virtually in October 2022 with discussions resulting in this upgraded...