Drew M Lowery
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Explore the profile of Drew M Lowery including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
1200
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Recent Articles
1.
Burkard M, Maciejowski J, Rodriguez-Bravo V, Repka M, Lowery D, Clauser K, et al.
PLoS Biol
. 2009 May;
7(5):e1000111.
PMID: 19468302
Animal cells initiate cytokinesis in parallel with anaphase onset, when an actomyosin ring assembles and constricts through localized activation of the small GTPase RhoA, giving rise to a cleavage furrow....
2.
Mazanka E, Alexander J, Yeh B, Charoenpong P, Lowery D, Yaffe M, et al.
PLoS Biol
. 2008 Aug;
6(8):e203.
PMID: 18715118
Cell fate can be determined by asymmetric segregation of gene expression regulators. In the budding yeast Saccharomyces cerevisiae, the transcription factor Ace2 accumulates specifically in the daughter cell nucleus, where...
3.
Snead J, Sullivan M, Lowery D, Cohen M, Zhang C, Randle D, et al.
Chem Biol
. 2007 Nov;
14(11):1261-72.
PMID: 18022565
Protein phosphorylation is a ubiquitous mechanism for cellular signal propagation, and signaling network complexity presents a challenge to protein kinase substrate identification. Few targets of Polo-like kinases are known, despite...
4.
Lowery D, Clauser K, Hjerrild M, Lim D, Alexander J, Kishi K, et al.
EMBO J
. 2007 Apr;
26(9):2262-73.
PMID: 17446864
Polo-like kinase-1 (Plk1) phosphorylates a number of mitotic substrates, but the diversity of Plk1-dependent processes suggests the existence of additional targets. Plk1 contains a specialized phosphoserine-threonine binding domain, the Polo-box...
5.
Yoshida S, Kono K, Lowery D, Bartolini S, Yaffe M, Ohya Y, et al.
Science
. 2006 Jun;
313(5783):108-11.
PMID: 16763112
The links between the cell cycle machinery and the cytoskeletal proteins controlling cytokinesis are poorly understood. The small guanine nucleotide triphosphate (GTP)-binding protein RhoA stimulates type II myosin contractility and...
6.
Russ W, Lowery D, Mishra P, Yaffe M, Ranganathan R
Nature
. 2005 Sep;
437(7058):579-83.
PMID: 16177795
Protein sequences evolve through random mutagenesis with selection for optimal fitness. Cooperative folding into a stable tertiary structure is one aspect of fitness, but evolutionary selection ultimately operates on function,...
7.
Lowery D, Lim D, Yaffe M
Oncogene
. 2005 Jan;
24(2):248-59.
PMID: 15640840
Polo-like kinases play critical roles during multiple stages of cell cycle progression. All Polo-like kinases contain an N-terminal Ser/Thr kinase catalytic domain and a C-terminal region that contains one or...
8.
Alexander D, Kaczorowski D, Jackson-Fisher A, Lowery D, Zanton S, Pugh B
J Biol Chem
. 2004 Jun;
279(31):32401-6.
PMID: 15190063
The Brf1 subunit of TFIIIB plays an important role in recruiting the TATA-binding protein (TBP) to the up-stream region of genes transcribed by RNA polymerase III. When TBP is not...
9.
Clapperton J, Manke I, Lowery D, Ho T, Haire L, Yaffe M, et al.
Nat Struct Mol Biol
. 2004 May;
11(6):512-8.
PMID: 15133502
Germline mutations in the BRCA1 tumor suppressor gene often result in a significant increase in susceptibility to breast and ovarian cancers. Although the molecular basis of their effects remains largely...
10.
The Polo-box domain: a molecular integrator of mitotic kinase cascades and Polo-like kinase function
Lowery D, Mohammad D, Elia A, Yaffe M
Cell Cycle
. 2004 Jan;
3(2):128-31.
PMID: 14712072
No abstract available.