Isaac A Manke
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Explore the profile of Isaac A Manke including associated specialties, affiliations and a list of published articles.
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6
Citations
690
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Recent Articles
1.
Manke I, Yaffe M
CSH Protoc
. 2011 Mar;
2007:pdb.prot4640.
PMID: 21357059
INTRODUCTIONThis protocol describes a method for oriented peptide library screening. This method, combined with bioinformatics-based searches of protein sequence databases, provides a strategy for identifying substrates of particular protein kinases,...
2.
Ahonen L, Kallio M, Daum J, Bolton M, Manke I, Yaffe M, et al.
Curr Biol
. 2005 Jun;
15(12):1078-89.
PMID: 15964272
Background: In mitosis, a mechanochemical system recognizes tension that is generated by bipolar microtubule attachment to sister kinetochores. This is translated into multiple outputs including the stabilization of microtubule attachments,...
3.
Manke I, Nguyen A, Lim D, Stewart M, Elia A, Yaffe M
Mol Cell
. 2005 Jan;
17(1):37-48.
PMID: 15629715
The cellular response to DNA damage is mediated by evolutionarily conserved Ser/Thr kinases, phosphorylation of Cdc25 protein phosphatases, binding to 14-3-3 proteins, and exit from the cell cycle. To investigate...
4.
Clapperton J, Manke I, Lowery D, Ho T, Haire L, Yaffe M, et al.
Nat Struct Mol Biol
. 2004 May;
11(6):512-8.
PMID: 15133502
Germline mutations in the BRCA1 tumor suppressor gene often result in a significant increase in susceptibility to breast and ovarian cancers. Although the molecular basis of their effects remains largely...
5.
Manke I, Lowery D, Nguyen A, Yaffe M
Science
. 2003 Oct;
302(5645):636-9.
PMID: 14576432
We used a proteomic approach to identify phosphopeptide-binding modules mediating signal transduction events in the DNA damage response pathway. Using a library of partially degenerate phosphopeptides, we identified tandem BRCT...
6.