David Pellman
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Explore the profile of David Pellman including associated specialties, affiliations and a list of published articles.
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93
Citations
11678
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Recent Articles
1.
Zhang C, Pellman D
bioRxiv
. 2024 Sep;
PMID: 39229211
DNA rearrangements are thought to arise from two classes of processes. The first class involves DNA breakage and fusion ("cut-and-paste") without net DNA gain or loss. The second class involves...
2.
Brunette G, Tourdot R, Wangsa D, Pellman D, Zhang C
bioRxiv
. 2024 Mar;
PMID: 38496539
Genomic characterization has revealed widespread structural complexity in cancer karyotypes, however shotgun sequencing cannot resolve genomic rearrangements with chromosome-length continuity. Here, we describe a two-tiered approach to determine the segmental...
3.
Coy S, Cheng B, Lee J, Rashid R, Browning L, Xu Y, et al.
bioRxiv
. 2023 Nov;
PMID: 37986801
Nuclear atypia, including altered nuclear size, contour, and chromatin organization, is ubiquitous in cancer cells. Atypical primary nuclei and micronuclei can rupture during interphase; however, the frequency, causes, and consequences...
4.
Papathanasiou S, Mynhier N, Liu S, Brunette G, Stokasimov E, Jacob E, et al.
Nature
. 2023 Jun;
619(7968):184-192.
PMID: 37286600
Transcriptional heterogeneity due to plasticity of the epigenetic state of chromatin contributes to tumour evolution, metastasis and drug resistance. However, the mechanisms that cause this epigenetic variation are incompletely understood....
5.
Lee J, Jung Y, Cheong T, Espejo Valle-Inclan J, Chu C, Gulhan D, et al.
Nature
. 2023 May;
618(7967):1024-1032.
PMID: 37198482
Focal copy-number amplification is an oncogenic event. Although recent studies have revealed the complex structure and the evolutionary trajectories of oncogene amplicons, their origin remains poorly understood. Here we show...
6.
Zhao G, Liu S, Arun S, Renda F, Khodjakov A, Pellman D
Dev Cell
. 2023 Apr;
58(10):847-865.e10.
PMID: 37098350
Nuclear envelope (NE) assembly defects cause chromosome fragmentation, cancer, and aging. However, major questions about the mechanism of NE assembly and its relationship to nuclear pathology are unresolved. In particular,...
7.
Tang S, Stokasimov E, Cui Y, Pellman D
Nature
. 2022 Apr;
606(7916):930-936.
PMID: 35477155
Chromothripsis is a catastrophic mutational process that promotes tumorigenesis and causes congenital disease. Chromothripsis originates from aberrations of nuclei called micronuclei or chromosome bridges. These structures are associated with fragile...
8.
9.
Papathanasiou S, Markoulaki S, Blaine L, Leibowitz M, Zhang C, Jaenisch R, et al.
Nat Commun
. 2021 Oct;
12(1):5855.
PMID: 34615869
Karyotype alterations have emerged as on-target complications from CRISPR-Cas9 genome editing. However, the events that lead to these karyotypic changes in embryos after Cas9-treatment remain unknown. Here, using imaging and...
10.
Leibowitz M, Papathanasiou S, Doerfler P, Blaine L, Sun L, Yao Y, et al.
Nat Genet
. 2021 Apr;
53(6):895-905.
PMID: 33846636
Genome editing has therapeutic potential for treating genetic diseases and cancer. However, the currently most practicable approaches rely on the generation of DNA double-strand breaks (DSBs), which can give rise...