Douglas MacNeil
Overview
Explore the profile of Douglas MacNeil including associated specialties, affiliations and a list of published articles.
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Articles
3
Citations
56
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0
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Recent Articles
1.
Hoyt S, Taylor J, London C, Ali A, Ujjainwalla F, Tata J, et al.
Bioorg Med Chem Lett
. 2017 Apr;
27(11):2384-2388.
PMID: 28416132
We report the discovery and hit-to-lead optimization of a structurally novel indazole series of CYP11B2 inhibitors. Benchmark compound 34 from this series displays potent inhibition of CYP11B2, high selectivity versus...
2.
Ronnebaum S, Jensen M, Hohmeier H, Burgess S, Zhou Y, Qian S, et al.
J Biol Chem
. 2008 Aug;
283(43):28909-17.
PMID: 18755687
We have previously demonstrated a role for pyruvate cycling in glucose-stimulated insulin secretion (GSIS). Some of the possible pyruvate cycling pathways are completed by conversion of malate to pyruvate by...
3.
Van der Ploeg L, Kanatani A, MacNeil D, Ming Fong T, Strack A, Nargund R, et al.
Prog Brain Res
. 2006 Aug;
153:107-18.
PMID: 16876570
Over the past decade, hypothalamic circuits have been described that impact energy homeostasis in rodents and humans. Our drug development efforts for the treatment of obesity and the metabolic syndrome...