Douglas M Tollefsen
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Explore the profile of Douglas M Tollefsen including associated specialties, affiliations and a list of published articles.
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24
Citations
440
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Recent Articles
1.
Marjoram R, Li Z, He L, Tollefsen D, Kunicki T, Dickeson S, et al.
PLoS One
. 2014 Nov;
9(11):e114035.
PMID: 25415203
Objective: Platelets express the α2β1 integrin and the glycoprotein VI (GPVI)/FcRγ complex, both collagen receptors. Understanding platelet-collagen receptor function has been enhanced through use of genetically modified mouse models. Previous...
2.
Kalle M, Papareddy P, Kasetty G, Tollefsen D, Malmsten M, Morgelin M, et al.
J Immunol
. 2013 May;
190(12):6303-10.
PMID: 23656734
The abundant serine proteinase inhibitor heparin cofactor II (HCII) has been proposed to inhibit extravascular thrombin. However, the exact physiological role of this plasma protein remains enigmatic. In this study,...
3.
Charles J, Coury F, Sulyanto R, Sitara D, Wu J, Brady N, et al.
Bone
. 2012 Sep;
51(5):902-12.
PMID: 22985540
Osteoclasts are specialized secretory cells of the myeloid lineage important for normal skeletal homeostasis as well as pathologic conditions of bone including osteoporosis, inflammatory arthritis and cancer metastasis. Differentiation of...
4.
Vicente C, Weiler H, Di Cera E, Tollefsen D
Thromb Res
. 2011 Dec;
130(4):646-8.
PMID: 22178578
Introduction: The thrombin mutant W215A/E217A (WE thrombin) has greatly reduced procoagulant activity, but it activates protein C in the presence of thrombomodulin and inhibits binding of platelet glycoprotein Ib to...
5.
Ndonwi M, Burlingame O, Miller A, Tollefsen D, Broze Jr G, Goldberg D
Blood
. 2011 Apr;
117(23):6347-54.
PMID: 21511958
Histidine-rich protein II (HRPII) is an abundant protein released into the bloodstream by Plasmodium falciparum, the parasite that causes the most severe form of human malaria. Here, we report that...
6.
Godoy J, Block D, Tollefsen D, Werneck C, Vicente C
Cytotherapy
. 2011 Jan;
13(6):695-704.
PMID: 21250866
Background Aims: Previously, we have demonstrated that administration of dermatan sulfate (DS) suppresses neointima formation in the mouse carotid artery by activating heparin co-factor II. A similar suppressive effect was...
7.
Tollefsen D
Prog Mol Biol Transl Sci
. 2010 Sep;
93:351-72.
PMID: 20807652
Heparin cofactor II (HCII) is a plasma protease inhibitor of the serpin family that inactivates thrombin by forming a covalent 1:1 complex. The rate of complex formation increases more than...
8.
Sarilla S, Habib S, Tollefsen D, Friedman D, Arnett D, Verhamme I
Anal Biochem
. 2010 Jul;
406(2):166-75.
PMID: 20670608
Irreversible inactivation of alpha-thrombin (T) by the serpin, heparin cofactor II (HCII), is accelerated by ternary complex formation with the glycosaminoglycans (GAGs) heparin and dermatan sulfate (DS). Low expression of...
9.
Metcalf J, Ma X, Linders B, Wu S, Schambach A, Ohlemiller K, et al.
Mol Ther
. 2009 Oct;
18(2):334-42.
PMID: 19844196
Mucopolysaccharidosis I (MPS I) is a lysosomal storage disease due to deficiency in alpha-L-iduronidase (IDUA) that results in accumulation of glycosaminoglycans (GAGs) throughout the body, causing numerous clinical defects. Intravenous...
10.
He L, K Giri T, Vicente C, Tollefsen D
Blood
. 2008 Feb;
111(8):4118-25.
PMID: 18281504
Heparin cofactor II (HCII)-deficient mice form occlusive thrombi more rapidly than do wild-type mice following injury to the carotid arterial endothelium. Dermatan sulfate (DS) and heparan sulfate (HS) increase the...