Douglas H Turner
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Explore the profile of Douglas H Turner including associated specialties, affiliations and a list of published articles.
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105
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3438
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Recent Articles
11.
Berger K, Kennedy S, Schroeder S, Znosko B, Sun H, Mathews D, et al.
Biochemistry
. 2018 Mar;
57(14):2121-2131.
PMID: 29570276
GU base pairs are important RNA structural motifs and often close loops. Accurate prediction of RNA structures relies upon understanding the interactions determining structure. The thermodynamics of some 2 ×...
12.
Spasic A, Kennedy S, Needham L, Manoharan M, Kierzek R, Turner D, et al.
RNA
. 2018 Feb;
24(5):656-672.
PMID: 29434035
The RNA "GAGU" duplex, (5'GACGUCA), contains the internal loop (5'-GAGU-3') , which has two conformations in solution as determined by NMR spectroscopy. The major conformation has a loop structure consisting...
13.
Smith L, Zhao J, Mathews D, Turner D
Wiley Interdiscip Rev RNA
. 2017 Aug;
8(5).
PMID: 28815951
The database of RNA sequences is exploding, but knowledge of energetics, structures, and dynamics lags behind. All-atom computational methods, such as molecular dynamics, hold promise for closing this gap. New...
14.
Kauffmann A, Kennedy S, Zhao J, Turner D
Biochemistry
. 2017 Jul;
56(29):3733-3744.
PMID: 28700212
The prediction of RNA three-dimensional structure from sequence alone has been a long-standing goal. High-resolution, experimentally determined structures of simple noncanonical pairings and motifs are critical to the development of...
15.
Pinamonti G, Zhao J, Condon D, Paul F, Noe F, Turner D, et al.
J Chem Theory Comput
. 2016 Dec;
13(2):926-934.
PMID: 28001394
Nowadays different experimental techniques, such as single molecule or relaxation experiments, can provide dynamic properties of biomolecular systems, but the amount of detail obtainable with these methods is often limited...
16.
Mathews D, Turner D, Watson R
Curr Protoc Nucleic Acid Chem
. 2016 Dec;
67:11.2.1-11.2.19.
PMID: 27911493
In this unit, protocols are provided for predicting RNA secondary structure with the user-friendly RNAstructure desktop computer program and the RNAstructure Web server. The minimum free energy structure and a...
17.
Chen J, Bellaousov S, Turner D
Methods Mol Biol
. 2016 Sep;
1490:177-86.
PMID: 27665599
Dynamic programming methods for predicting RNA secondary structure often use thermodynamics and experimental restraints and/or constraints to limit folding space. Chemical mapping results typically restrain certain nucleotides not to be...
18.
Lenartowicz E, Nogales A, Kierzek E, Kierzek R, Martinez-Sobrido L, Turner D
Nucleic Acid Ther
. 2016 Jul;
26(5):277-285.
PMID: 27463680
Influenza A virus (IAV) affects 5%-10% of the world's population every year. Through genome changes, many IAV strains develop resistance to currently available anti-influenza therapeutics. Therefore, there is an urgent...
19.
Gleghorn M, Zhao J, Turner D, Maquat L
Nucleic Acids Res
. 2016 Jun;
44(17):8417-24.
PMID: 27288442
We have solved at 1. 07: Å resolution the X-ray crystal structure of a polyriboadenylic acid (poly(rA)) parallel and continuous double helix. Fifty-nine years ago, double helices of poly(rA) were...
20.
Jiang T, Nogales A, Baker S, Martinez-Sobrido L, Turner D
PLoS One
. 2016 Jun;
11(6):e0156906.
PMID: 27272307
Influenza A virus is a significant public health threat, but little is understood about the viral RNA structure and function. Current vaccines and therapeutic options to control influenza A virus...