Doug E Frantz
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Explore the profile of Doug E Frantz including associated specialties, affiliations and a list of published articles.
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Articles
41
Citations
1103
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Recent Articles
1.
Clanton N, Wilson N, Ortiz E, Blumberg S, Frantz D
Org Lett
. 2023 Jan;
25(1):277-281.
PMID: 36592432
The site-selective functionalization of unactivated allylic C-H bonds via direct deprotonation using KTMP is described. The conversion of amorphadiene to artemisinic alcohol via a simple, highly regioselective deprotonation over 4...
2.
Schneider J, Oommen S, Qureshi M, Goetsch S, Pease D, Sundsbak R, et al.
Nat Med
. 2021 Jun;
27(7):1309.
PMID: 34079106
No abstract available.
3.
Clanton N, Spiller T, Ortiz E, Gao Z, Rodriguez-Poirier J, DelMonte A, et al.
Org Lett
. 2021 Feb;
23(9):3233-3236.
PMID: 33630601
A simple metal-free method has been developed for the reductive N-alkylation of indoles employing aldehydes as the alkylating agent and inexpensive EtSiH as the reductant. A wide range of aromatic...
4.
Clanton N, Hastings S, Foultz G, Contreras J, Yee S, Arman H, et al.
ACS Med Chem Lett
. 2020 Dec;
11(12):2534-2543.
PMID: 33335677
Natural products have served as inspirational scaffolds for the design and synthesis of novel antineoplastic agents. Here we present our preliminary efforts on the synthesis and biological evaluation of a...
5.
Schneider J, Oommen S, Qureshi M, Goetsch S, Pease D, Sundsbak R, et al.
Nat Med
. 2020 Nov;
26(11):1788-1800.
PMID: 33188278
Ribonucleoprotein (RNP) granules are biomolecular condensates-liquid-liquid phase-separated droplets that organize and manage messenger RNA metabolism, cell signaling, biopolymer assembly, biochemical reactions and stress granule responses to cellular adversity. Dysregulated RNP...
6.
Munteanu C, Spiller T, Qiu J, DelMonte A, Wisniewski S, Simmons E, et al.
J Org Chem
. 2020 Jul;
85(16):10334-10349.
PMID: 32662636
Despite recent advancements in metal-catalyzed borylations of aryl (pseudo)halides, there is a continuing need to develop robust methods to access both early-stage and late-stage organoboron intermediates amendable for further functionalization....
7.
Du L, Munteanu C, King J, Frantz D, Cichewicz R
J Nat Prod
. 2019 Jul;
82(7):1989-1999.
PMID: 31273979
The anal secretions of skunks comprise several types of malodorous organosulfur compounds. The pungent metabolites are used defensively by skunks to repel threats posed by predators, and in many parts...
8.
Neff R, Frantz D
J Am Chem Soc
. 2018 Dec;
140(50):17428-17432.
PMID: 30521312
The cationic alkynyl Heck reaction between aryl triflates and alkynes to give substituted allenes is described. Key to the success of this method was the discovery and development of a...
9.
Stevens J, Parra-Rivera A, Dixon D, Beutner G, DelMonte A, Frantz D, et al.
J Org Chem
. 2018 Nov;
83(23):14245-14261.
PMID: 30412670
The identification of Yb(OTf) through a multivariable high-throughput experimentation strategy has enabled a unified protocol for the direct conversion of enantioenriched N-acyloxazolidinones to the corresponding chiral esters, amides, and carboxylic...
10.
El Arba M, Dibrell S, Meece F, Frantz D
Org Lett
. 2018 Sep;
20(18):5886-5888.
PMID: 30204453
The synthesis of densely functionalized trisubstituted and tetrasubstituted furans via a novel Ru(II)-catalyzed intramolecular cyclization of vinyl diazoesters is reported. The synthetic utility of these furans is further demonstrated through...