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Ian T Crouch

Explore the profile of Ian T Crouch including associated specialties, affiliations and a list of published articles. Areas
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Recent Articles
1.
Li H, Sheeran J, Kouvchinov D, Clausen A, Crouch I, Bio M, et al.
J Org Chem . 2021 Aug; 87(4):2045-2054. PMID: 34374277
The ketone intermediate LSN647712 is a key synthetic intermediate for the drug substance lasmiditan manufacturing process. A three-step connected continuous flow process utilizing a Turbo Grignard reagent, -methylpiperidin-4-ylmagnesium chloride, and...
2.
Lehmann J, Crouch I, Blair D, Trobe M, Wang P, Li J, et al.
Nat Commun . 2019 Mar; 10(1):1263. PMID: 30894535
Stereocontrolled Csp cross-coupling can fundamentally change the types of chemical structures that can be mined for molecular functions. Although considerable progress in achieving the targeted chemical reactivity has been made,...
3.
El Arba M, Dibrell S, Crouch I, Frantz D
Org Lett . 2017 Sep; 19(19):5446-5449. PMID: 28953409
A robust synthesis of allenoates via a Pd-catalyzed β-hydride elimination of (E)-enol triflates is presented. Salient features of this method include low catalyst loadings, mild reaction conditions, and the ability...
4.
Crouch I, Neff R, Frantz D
J Am Chem Soc . 2013 Mar; 135(13):4970-3. PMID: 23488914
We wish to report our preliminary results on the discovery and development of a catalytic, asymmetric β-hydride elimination from vinyl Pd(II)-complexes derived from enol triflates to access chiral allenes. To...
5.
Crouch I, Dreier T, Frantz D
Angew Chem Int Ed Engl . 2011 May; 50(27):6128-32. PMID: 21574234
No abstract available.