Dorothea Zahner
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Explore the profile of Dorothea Zahner including associated specialties, affiliations and a list of published articles.
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15
Citations
517
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Recent Articles
1.
Chancey S, Zahner D, Stephens D
Future Microbiol
. 2012 Aug;
7(8):959-78.
PMID: 22913355
A major contributor to the emergence of antibiotic resistance in Gram-positive bacterial pathogens is the expansion of acquired, inducible genetic elements. Although acquired, inducible antibiotic resistance is not new, the...
2.
Zahner D, Gandhi A, Yi H, Stephens D
PLoS One
. 2011 Oct;
6(9):e25124.
PMID: 21966432
Background: Streptococcus oralis, Streptococcus mitis, and Streptococcus sanguinis are members of the Mitis group of streptococci and agents of oral biofilm, dental plaque and infective endocarditis, disease processes that involve...
3.
Vidal J, Ludewick H, Kunkel R, Zahner D, Klugman K
Infect Immun
. 2011 Aug;
79(10):4050-60.
PMID: 21825061
Streptococcus pneumoniae is the leading cause of death in children worldwide and forms highly organized biofilms in the nasopharynx, lungs, and middle ear mucosa. The luxS-controlled quorum-sensing (QS) system has...
4.
Zahner D, Gandhi A, Stuchlik O, Reed M, Pohl J, Stephens D
Biochem Biophys Res Commun
. 2011 May;
409(3):526-31.
PMID: 21600877
Streptococcus pneumoniae type 2 pili are recently identified fimbrial structures extending from the bacterial surface and formed by polymers of the structural protein PitB. Intramolecular isopeptide bonds are a characteristic...
5.
Chancey S, Zhou X, Zahner D, Stephens D
Antimicrob Agents Chemother
. 2011 May;
55(7):3413-22.
PMID: 21537010
The antimicrobial efflux system encoded by the operon mef(E)-mel on the mobile genetic element MEGA in Streptococcus pneumoniae and other Gram-positive bacteria is inducible by macrolide antibiotics and antimicrobial peptides....
6.
Rohde M, Graham R, Branitzki-Heinemann K, Borchers P, Preuss C, Schleicher I, et al.
Cell Microbiol
. 2010 Nov;
13(3):450-68.
PMID: 21054741
Group A streptococci (GAS, Streptococcus pyogenes) and Group G streptococci (GGS, Streptococcus dysgalactiae ssp. equisimilis) adhere to and invade host cells by binding to fibronectin. The fibronectin-binding protein SfbI from...
7.
Kaur S, Nerlich A, Bergmann S, Rohde M, Fulde M, Zahner D, et al.
J Biol Chem
. 2010 Jun;
285(36):27798-805.
PMID: 20562101
Streptococcus pyogenes expresses the LPXTG motif-containing cell envelope serine protease SpyCep (also called ScpC, PrtS) that degrades and inactivates the major chemoattractant interleukin 8 (IL-8), thereby impairing host neutrophil recruitment....
8.
Zahner D, Gudlavalleti A, Stephens D
Emerg Infect Dis
. 2010 May;
16(6):955-62.
PMID: 20507746
To define the prevalence of pilus islet 2 (PI-2)-encoded pili in Streptococcus pneumoniae in a geographically defined area, we examined 590 S. pneumoniae isolates from population-based surveillance of invasive pneumococcal...
9.
Zahner D, Zhou X, Chancey S, Pohl J, Shafer W, Stephens D
Antimicrob Agents Chemother
. 2010 May;
54(8):3516-9.
PMID: 20498319
Macrolide resistance is a major concern in the treatment of Streptococcus pneumoniae. Inducible macrolide resistance in this pneumococcus is mediated by the efflux pump MefE/Mel. We show here that the...
10.
Quigley B, Zahner D, Hatkoff M, Thanassi D, Scott J
Mol Microbiol
. 2009 May;
72(6):1379-94.
PMID: 19432798
The important human pathogen Streptococcus pyogenes (group A streptococcus, GAS) initiates infection by pilus-mediated attachment to host tissue. Thus, the pilus is an excellent target for design of anti-infective strategies....