Doron C Greenbaum
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Explore the profile of Doron C Greenbaum including associated specialties, affiliations and a list of published articles.
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27
Citations
1457
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Recent Articles
1.
Goldberg J, Chen X, Meinhardt N, Greenbaum D, Petersson E
J Am Chem Soc
. 2014 Jan;
136(5):2086-93.
PMID: 24472041
Thioamide quenchers can be paired with compact fluorophores to design "turn-on" fluorescent protease substrates. We have used this method to study a variety of serine-, cysteine-, carboxyl-, and metallo-proteases, including...
2.
Millholland M, Mishra S, Dupont C, Love M, Patel B, Shilling D, et al.
Cell Host Microbe
. 2013 Jan;
13(1):15-28.
PMID: 23332153
Following intracellular replication, the apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii cause host cell cytolysis to facilitate parasite release and disease progression. Parasite exit from infected cells requires the interplay...
3.
Love M, Millholland M, Mishra S, Kulkarni S, Freeman K, Pan W, et al.
Cell Host Microbe
. 2012 Dec;
12(6):815-23.
PMID: 23245326
Plasmodium falciparum pathogenesis is affected by various cell types in the blood, including platelets, which can kill intraerythrocytic malaria parasites. Platelets could mediate these antimalarial effects through human defense peptides...
4.
Harbut M, Patel B, Yeung B, McNamara C, Bright A, Ballard J, et al.
Proc Natl Acad Sci U S A
. 2012 Dec;
109(52):21486-91.
PMID: 23236186
Early secretory and endoplasmic reticulum (ER)-localized proteins that are terminally misfolded or misassembled are degraded by a ubiquitin- and proteasome-mediated process known as ER-associated degradation (ERAD). Protozoan pathogens, including the...
5.
Jo H, Meinhardt N, Wu Y, Kulkarni S, Hu X, Low K, et al.
J Am Chem Soc
. 2012 Sep;
134(42):17704-13.
PMID: 22998171
We have designed a highly specific inhibitor of calpain by mimicking a natural protein-protein interaction between calpain and its endogenous inhibitor calpastatin. To enable this goal we established a new...
6.
Onder O, Humphrey P, McOmber B, Korobova F, Francella N, Greenbaum D, et al.
J Biol Chem
. 2012 Mar;
287(20):16860-8.
PMID: 22433849
Host-derived proteases are crucial for the successful infection of vertebrates by several pathogens, including the Lyme disease spirochete bacterium, Borrelia burgdorferi. B. burgdorferi must traverse tissue barriers in the tick...
7.
Doyle P, Zhou Y, Hsieh I, Greenbaum D, McKerrow J, Engel J
PLoS Pathog
. 2011 Sep;
7(9):e1002139.
PMID: 21909255
Trypanosoma cruzi is the causative agent of Chagas' disease. Novel chemotherapy with the drug K11777 targets the major cysteine protease cruzain and disrupts amastigote intracellular development. Nevertheless, the biological role...
8.
The malaria parasite progressively dismantles the host erythrocyte cytoskeleton for efficient egress
Millholland M, Chandramohanadas R, Pizzarro A, Wehr A, Shi H, Darling C, et al.
Mol Cell Proteomics
. 2011 Sep;
10(12):M111.010678.
PMID: 21903871
Plasmodium falciparum is an obligate intracellular pathogen responsible for worldwide morbidity and mortality. This parasite establishes a parasitophorous vacuole within infected red blood cells wherein it differentiates into multiple daughter...
9.
Harbut M, Velmourougane G, Dalal S, Reiss G, Whisstock J, Onder O, et al.
Proc Natl Acad Sci U S A
. 2011 Aug;
108(34):E526-34.
PMID: 21844374
Malaria causes worldwide morbidity and mortality, and while chemotherapy remains an excellent means of malaria control, drug-resistant parasites necessitate the discovery of new antimalarials. Peptidases are a promising class of...
10.
Kalinska M, Kantyka T, Greenbaum D, Larsen K, Wladyka B, Jabaiah A, et al.
Biochimie
. 2011 Aug;
94(2):318-27.
PMID: 21802486
Human strains of Staphylococcus aureus secrete two papain-like proteases, staphopain A and B. Avian strains produce another homologous enzyme, staphopain C. Animal studies suggest that staphopains B and C contribute...