Dorit Ben-Shachar
Overview
Explore the profile of Dorit Ben-Shachar including associated specialties, affiliations and a list of published articles.
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49
Citations
1142
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Recent Articles
1.
Sarnyai Z, Ben-Shachar D
Psychiatry Res
. 2024 Oct;
342:116220.
PMID: 39369460
Schizophrenia is a chronic, neurodevelopmental disorder with unknown aetiology and pathophysiology that emphasises the role of neurotransmitter imbalance and abnormalities in synaptic plasticity. The currently used pharmacological approach, the antipsychotic...
2.
Tripathi K, Ben-Shachar D
Cells
. 2024 Mar;
13(5.
PMID: 38474374
Mitochondria, the energy suppliers of the cells, play a central role in a variety of cellular processes essential for survival or leading to cell death. Consequently, mitochondrial dysfunction is implicated...
3.
Ene H, Karry R, Farfara D, Ben-Shachar D
Mol Psychiatry
. 2022 Nov;
28(3):1170-1181.
PMID: 36380234
Ample evidence implicate mitochondria in early brain development. However, to the best of our knowledge, there is only circumstantial data for mitochondria involvement in late brain development occurring through adolescence,...
4.
Yatchenko Y, Ben-Shachar D
Methods Mol Biol
. 2021 Jun;
2277:187-201.
PMID: 34080153
Mitochondria, similar to living cells and organelles, have a negative membrane potential, which ranges between (-108) and (150) mV as compared to (-70) and (-90) mV of the plasma membrane....
5.
Bar-Yosef T, Hussein W, Yitzhaki O, Damri O, Givon L, Marom C, et al.
Sci Rep
. 2020 Jul;
10(1):12258.
PMID: 32703977
Pharmacological treatment of mental disorders is currently decided based on "trial and error" strategy. Mitochondrial multifaceted dysfunction is assumed to be a major factor in the pathophysiology and treatment of...
6.
Ben-Shachar D
J Neural Transm (Vienna)
. 2019 Dec;
127(2):159-168.
PMID: 31848775
Parkinson's disease (PD) and schizophrenia (SZ) are two CNS disorders in which dysfunctions in the dopaminergic system and mitochondria are major pathologies. The symptomology of both, PD a neurodegenerative disorder...
7.
Ifhar L, Ene H, Ben-Shachar D
Eur Neuropsychopharmacol
. 2019 Apr;
29(5):577-589.
PMID: 30948194
Accumulating data point to heme involvement in neuropsychiatric disorders. Heme plays a role in major cellular processes such as signal transduction, protein complex assembly and regulation of transcription and translation....
8.
Bergman O, Karry R, Milhem J, Ben-Shachar D
Mol Psychiatry
. 2018 Dec;
25(4):805-820.
PMID: 30531937
Mitochondria together with other cellular components maintain a constant crosstalk, modulating transcriptional and posttranslational processes. We and others demonstrated mitochondrial multifaceted dysfunction in schizophrenia, with aberrant complex I (CoI) as...
9.
Re S, Dogan A, Ben-Shachar D, Berger G, Werling A, Walitza S, et al.
Front Cell Neurosci
. 2018 Oct;
12:321.
PMID: 30319360
In the last decade, there is an increasing application of induced pluripotent stem cells (iPSCs) for disease modeling. The iPSC technology enables the study of patient-specific neuronal cell lines to...
10.
Asor E, Ben-Shachar D
Clin Exp Pharmacol Physiol
. 2018 Jun;
45(10):1028-1037.
PMID: 29851136
Chemotherapy-induced cognitive changes is a major burden on a substantial number of cancer survivors. The mechanism of this sequel is unknown. In this study, we followed long-term effects of early...