Doreen E Culham
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Explore the profile of Doreen E Culham including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
439
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Recent Articles
1.
Ozturk T, Coumoundouros C, Culham D, Wood J
Biochemistry
. 2022 Dec;
62(1):118-133.
PMID: 36516499
Osmosensing transporter ProP forestalls cellular dehydration by detecting environments with high osmotic pressure and mediating the accumulation of organic osmolytes by bacterial cells. It is composed of 12 transmembrane helices...
2.
Ozturk T, Culham D, Tempelhagen L, Wood J, Lamoureux G
J Phys Chem B
. 2020 Aug;
124(38):8209-8220.
PMID: 32838524
Osmosensing transporter ProP detects the increase in cytoplasmic cation concentration associated with osmotically induced cell dehydration and mediates osmolyte uptake into bacteria. ProP is a 12-transmembrane helix protein with an...
3.
Tempelhagen L, Ayer A, Culham D, Stocker R, Wood J
J Biol Chem
. 2020 Feb;
295(8):2542.
PMID: 32090977
No abstract available.
4.
Tempelhagen L, Ayer A, Culham D, Stocker R, Wood J
J Biol Chem
. 2019 Dec;
295(4):981-993.
PMID: 31826918
Ubiquinone 8 (coenzyme Q8 or Q8) mediates electron transfer within the aerobic respiratory chain, mitigates oxidative stress, and contributes to gene expression in In addition, Q8 was proposed to confer...
5.
Culham D, Marom D, Boutin R, Garner J, Ozturk T, Sahtout N, et al.
Biophys J
. 2018 Nov;
115(11):2152-2166.
PMID: 30448037
ProP is a member of the major facilitator superfamily, a proton-osmolyte symporter, and an osmosensing transporter. ProP proteins share extended cytoplasmic carboxyl terminal domains (CTDs) implicated in osmosensing. The CTDs...
6.
Culham D, Shkel I, Record Jr M, Wood J
Biochemistry
. 2018 Aug;
57(33):5072.
PMID: 30091603
No abstract available.
7.
Romantsov T, Gonzalez K, Sahtout N, Culham D, Coumoundouros C, Garner J, et al.
Mol Microbiol
. 2017 Dec;
107(5):623-638.
PMID: 29280215
Osmosensing by transporter ProP is modulated by its cardiolipin (CL)-dependent concentration at the poles of Escherichia coli cells. Other contributors to this phenomenon were sought with the BACterial Two-Hybrid System...
8.
Romantsov T, Culham D, Caplan T, Garner J, Hodges R, Wood J
Mol Microbiol
. 2016 Nov;
103(3):469-482.
PMID: 27802568
Osmosensing transporter ProP protects bacteria from osmotically induced dehydration by mediating the uptake of zwitterionic osmolytes. ProP activity is a sigmoidal function of the osmolality. ProP orthologues share an extended,...
9.
Culham D, Shkel I, Record Jr M, Wood J
Biochemistry
. 2016 Feb;
55(9):1301-13.
PMID: 26871755
Osmosensing transporters mediate osmolyte accumulation to forestall cellular dehydration as the extracellular osmolality increases. ProP is a bacterial osmolyte-H(+) symporter, a major facilitator superfamily member, and a paradigm for osmosensing....
10.
Lang S, Cressatti M, Mendoza K, Coumoundouros C, Plater S, Culham D, et al.
Biochemistry
. 2015 Sep;
54(37):5735-47.
PMID: 26325238
Transporter-mediated osmolyte accumulation stimulates the growth of Escherichia coli in high-osmolality environments. YehZYXW was predicted to be an osmoregulatory transporter because (1) osmotic and stationary phase induction of yehZYXW is...