Donna J Thuerauf
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Explore the profile of Donna J Thuerauf including associated specialties, affiliations and a list of published articles.
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31
Citations
1629
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Recent Articles
1.
Bilal A, Parker S, Murray V, MacDonnell L, Thuerauf D, Glembotski C, et al.
Curr Protoc
. 2023 May;
3(5):e757.
PMID: 37166238
Genetic manipulation in vivo is a critical method for mechanistically understanding gene function in disease and physiological processes. To facilitate this, embryonic transgenesis in popular animal models like mice has...
2.
Blackwood E, MacDonnell L, Thuerauf D, Bilal A, Murray V, Bedi Jr K, et al.
Circulation
. 2022 Nov;
147(1):66-82.
PMID: 36317534
Background: Cardiac hypertrophy increases demands on protein folding, which causes an accumulation of misfolded proteins in the endoplasmic reticulum (ER). These misfolded proteins can be removed by the adaptive retrotranslocation,...
3.
Bilal A, Thuerauf D, Blackwood E, Glembotski C
Methods Mol Biol
. 2022 Aug;
2573:89-113.
PMID: 36040589
Adeno-associated virus serotype 9 (AAV9) is often used in heart research involving gene delivery due to its cardiotropism, high transduction efficiency, and little to no pathogenicity, making it highly applicable...
4.
Optimizing Adeno-Associated Virus Serotype 9 for Studies of Cardiac Chamber-Specific Gene Regulation
Bilal A, Blackwood E, Thuerauf D, Glembotski C
Circulation
. 2021 May;
143(20):2025-2027.
PMID: 33999662
No abstract available.
5.
Marsh K, Arrieta A, Thuerauf D, Blackwood E, MacDonnell L, Glembotski C
Am J Physiol Heart Circ Physiol
. 2021 Mar;
320(5):H1813-H1821.
PMID: 33666503
Although peroxisomes have been extensively studied in other cell types, their presence and function have gone virtually unexamined in cardiac myocytes. Here, in neonatal rat ventricular myocytes (NRVM) we showed...
6.
Blackwood E, Thuerauf D, Stastna M, Stephens H, Sand Z, Pentoney A, et al.
J Mol Cell Cardiol
. 2020 Apr;
143:132-144.
PMID: 32339566
The effects of ER stress on protein secretion by cardiac myocytes are not well understood. In this study, the ER stressor thapsigargin (TG), which depletes ER calcium, induced death of...
7.
Arrieta A, Blackwood E, Stauffer W, Domingo M, Bilal A, Thuerauf D, et al.
J Biol Chem
. 2020 Apr;
295(22):7566-7583.
PMID: 32327487
We have previously demonstrated that ischemia/reperfusion (I/R) impairs endoplasmic reticulum (ER)-based protein folding in the heart and thereby activates an unfolded protein response sensor and effector, activated transcription factor 6α...
8.
Blackwood E, Azizi K, Thuerauf D, Paxman R, Plate L, Kelly J, et al.
Nat Commun
. 2019 Jan;
10(1):187.
PMID: 30643122
Pharmacologic activation of stress-responsive signaling pathways provides a promising approach for ameliorating imbalances in proteostasis associated with diverse diseases. However, this approach has not been employed in vivo. Here we...
9.
Blackwood E, Hofmann C, Domingo M, Bilal A, Sarakki A, Stauffer W, et al.
Circ Res
. 2018 Dec;
124(1):79-93.
PMID: 30582446
Rationale: Endoplasmic reticulum (ER) stress dysregulates ER proteostasis, which activates the transcription factor, ATF6 (activating transcription factor 6α), an inducer of genes that enhance protein folding and restore ER proteostasis....
10.
Jin J, Blackwood E, Azizi K, Thuerauf D, Fahem A, Hofmann C, et al.
Circ Res
. 2016 Dec;
120(5):862-875.
PMID: 27932512
Rationale: Endoplasmic reticulum (ER) stress causes the accumulation of misfolded proteins in the ER, activating the transcription factor, ATF6 (activating transcription factor 6 alpha), which induces ER stress response genes....