Dongwei Kang
Overview
Explore the profile of Dongwei Kang including associated specialties, affiliations and a list of published articles.
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153
Citations
1219
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Recent Articles
1.
Zhou Z, Xie M, Zhuo Z, Wang Y, Zhao F, Tao S, et al.
Eur J Med Chem
. 2025 Mar;
289:117464.
PMID: 40048799
To promote the development of the new generation of HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs), a series of novel 2,4,5-trisubstituted pyrimidine derivatives targeting the "tolerant region I″ and "tolerant region...
2.
Jing L, Zhao F, Zheng L, Meng B, Gao S, Laporte M, et al.
Int J Mol Sci
. 2025 Jan;
26(2.
PMID: 39859382
With the aim of developing novel anti-SARS-CoV-2 drugs to address the ongoing evolution and emergence of drug-resistant strains, the reported SARS-CoV-2 M inhibitor was selected as a lead to find...
3.
Kang D
Animals (Basel)
. 2025 Jan;
15(2).
PMID: 39858117
This study analyzed survey result data of giant panda populations and habitats in the third and fourth giant panda surveys to reveal the population size-habitat area relationship and assess the...
4.
Zhao F, Jiang L, Xie J, Liu N, Gao Z, Yang Y, et al.
J Chem Inf Model
. 2025 Jan;
65(2):857-872.
PMID: 39809515
-Methyl-d-aspartate (NMDA) receptors, a subtype of ionotropic glutamate receptors in the central nervous system (CNS), have garnered attention for their role in brain disorders. Specifically, GluN2A-containing NMDA receptors have emerged...
5.
Dong T, Zhao F, Wang M, Lyu K, Zhu J, Zhang W, et al.
J Am Chem Soc
. 2024 Dec;
147(1):446-461.
PMID: 39710983
Stress granules (SGs) are membraneless cytoplasmic compartments that form in response to stress stimuli. In these compartments, most translation factors stall, except for activating transcription factor 4 (ATF4), which is...
6.
Zhuo Z, Wang Z, Jing L, Zhang T, Ge A, Zhou Z, et al.
Int J Mol Sci
. 2024 Aug;
25(16).
PMID: 39201714
Inspired by our previous work on the modification of diarylpyrimidine-typed non-nucleoside reverse transcriptase inhibitors (NNRTIs) and the reported crystallographic studies, a series of novel amino acids (analogues)-substituted thiophene[3,2-]pyrimidine derivatives were...
7.
Jing L, Wu G, Zhao F, Jiang X, Liu N, Feng D, et al.
Eur J Med Chem
. 2024 Aug;
277:116772.
PMID: 39167895
In addressing the urgent need for novel HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) to combat drug resistance, we employed CuAAC click chemistry to construct a diverse 312-member diarylpyrimidine (DAPY) derivative...
8.
Zhou Z, Sun Y, Qin Y, Wang N, Zhao F, Wang Z, et al.
Eur J Med Chem
. 2024 Aug;
277:116708.
PMID: 39094273
The rapid emergence of drug resistance severely reduces the clinical response of human immunodeficiency virus-1 (HIV-1) to non-nucleoside reverse transcriptase inhibitors (NNRTIs). Herein, a series of 2,4,6-trisubstituted pyrimidine derivatives was...
9.
Wang Z, Wang W, Gao Z, Gao H, De Clercq E, Pannecouque C, et al.
J Med Virol
. 2024 Jul;
96(8):e29830.
PMID: 39072764
In the current antiretroviral landscape, continuous efforts are still needed to search for novel chemotypes of human immunodeficiency virus type 1 (HIV-1) inhibitors with improved drug resistance profiles and favorable...
10.
Sun Y, Zhou Z, Shi Z, Zhao F, Xie M, Zhuo Z, et al.
Acta Pharm Sin B
. 2024 Jul;
14(7):3110-3124.
PMID: 39027243
HIV-1 reverse transcriptase (RT) has received great attention as an attractive therapeutic target for acquired immune deficiency syndrome (AIDS), but the inevitable drug resistance and side effects have always been...