Dominique Couton
Overview
Explore the profile of Dominique Couton including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
490
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Recent Articles
1.
Gentric G, Maillet V, Paradis V, Couton D, LHermitte A, Panasyuk G, et al.
J Clin Invest
. 2015 Jan;
125(3):981-92.
PMID: 25621497
Polyploidization is one of the most dramatic changes that can occur in the genome. In the liver, physiological polyploidization events occur during both liver development and throughout adult life. Here,...
2.
Pichard V, Couton D, Desdouets C, Ferry N
Hum Gene Ther
. 2012 Dec;
24(2):143-51.
PMID: 23249390
Lentiviral vectors are efficient gene delivery vehicles for therapeutic and research applications. In contrast to oncoretroviral vectors, they are able to infect most nonproliferating cells. In the liver, induction of...
3.
Celton-Morizur S, Merlen G, Couton D, Desdouets C
Cell Cycle
. 2010 Jan;
9(3):460-6.
PMID: 20090410
The formation of polyploid cells is part of the developmental program in several tissues. Polyploidy is a characteristic feature of mammalian hepatocytes and it is emerging that this process is...
4.
Mitchell C, Robin M, Mayeuf A, Mahrouf-Yorgov M, Mansouri A, Hamard M, et al.
Am J Pathol
. 2009 Oct;
175(5):1929-37.
PMID: 19808650
Accumulating evidence indicates that oxidative stress is involved in the physiopathology of liver fibrogenesis. However, amid the global context of hepatic oxidative stress, the specific role of hepatocyte mitochondrial dysfunction...
5.
Celton-Morizur S, Merlen G, Couton D, Margall-Ducos G, Desdouets C
J Clin Invest
. 2009 Jul;
119(7):1880-7.
PMID: 19603546
The formation of polyploid cells is part of the developmental program of several tissues. During postnatal development, binucleated tetraploid cells arise in the liver, caused by failure in cytokinesis. In...
6.
Mitchell C, Couton D, Couty J, Anson M, Crain A, Bizet V, et al.
Am J Pathol
. 2009 Apr;
174(5):1766-75.
PMID: 19359521
Inflammation has been shown to induce the progression of fibrosis in response to liver injury. Among inflammatory cells, macrophages and lymphocytes play major roles in both the constitution and resolution...
7.
Margall-Ducos G, Celton-Morizur S, Couton D, Bregerie O, Desdouets C
J Cell Sci
. 2007 Sep;
120(Pt 20):3633-9.
PMID: 17895361
Cytokinesis is precisely controlled in both time and space to ensure equal distribution of the genetic material between daughter cells. Incomplete cytokinesis can be associated with developmental or pathological cell...
8.
Brezillon N, Lambert-Blot M, Morosan S, Couton D, Mitchell C, Kremsdorf D, et al.
Mol Ther
. 2007 Jun;
15(9):1710-5.
PMID: 17565348
Orthotopic liver transplantation is limited by the shortage of liver donors, leading to elderly patients being enrolled as donors with increasing frequency. Alternative strategies such as cell therapy are therefore...
9.
Latasa M, Couton D, Charvet C, Lafanechere A, Guidotti J, Li Z, et al.
Am J Physiol Gastrointest Liver Physiol
. 2006 Dec;
292(4):G996-G1001.
PMID: 17170024
Various immediate early genes (IEGs) upregulated during the early process of liver regeneration are transcriptional targets of the serum response factor (SRF). We show here that the expression of SRF...
10.
Mitchell C, Mallet V, Guidotti J, Mignon A, Couton D, Kahn A, et al.
J Soc Biol
. 2006 Feb;
199(3):243-6.
PMID: 16471264
In the liver, the importance of apoptosis is not only evident during development and homeostasis of the biliary tree but plays also a prominent role in liver pathogenesis. Ligand binding...