Domenic Pilger
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Explore the profile of Domenic Pilger including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
423
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Recent Articles
1.
Kochenova O, DAlessandro G, Pilger D, Schmid E, Richards S, Garcia M, et al.
bioRxiv
. 2024 Sep;
PMID: 39282314
The E3 ubiquitin ligase TRAIP associates with the replisome and helps this molecular machine deal with replication stress. Thus, TRAIP promotes DNA inter-strand crosslink repair by triggering the disassembly of...
2.
Staniszewska A, Pilger D, Gill S, Jamal K, Bohin N, Guzzetti S, et al.
Clin Cancer Res
. 2023 Nov;
30(7):1338-1351.
PMID: 37967136
Purpose: We evaluated the properties and activity of AZD9574, a blood-brain barrier (BBB) penetrant selective inhibitor of PARP1, and assessed its efficacy and safety alone and in combination with temozolomide...
3.
Franz A, Valledor P, Ubieto-Capella P, Pilger D, Galarreta A, Lafarga V, et al.
Cell Rep
. 2021 Oct;
37(2):109819.
PMID: 34644576
The AAA ATPase VCP regulates the extraction of SUMO and ubiquitin-modified DNA replication factors from chromatin. We have previously described that active DNA synthesis is associated with a SUMO-high/ubiquitin-low environment...
4.
Pilger D, Seymour L, Jackson S
Genes Dev
. 2021 Apr;
35(9-10):602-618.
PMID: 33888558
The DNA damage response (DDR) fulfils essential roles to preserve genome integrity. Targeting the DDR in tumors has had remarkable success over the last decade, exemplified by the licensing of...
5.
Halder S, Torrecilla I, Burkhalter M, Popovic M, Fielden J, Vaz B, et al.
Nat Commun
. 2019 Jul;
10(1):3142.
PMID: 31316063
The SPRTN metalloprotease is essential for DNA-protein crosslink (DPC) repair and DNA replication in vertebrate cells. Cells deficient in SPRTN protease exhibit DPC-induced replication stress and genome instability, manifesting as...
6.
Balmus G, Pilger D, Coates J, Demir M, Sczaniecka-Clift M, Barros A, et al.
Nat Commun
. 2019 Jan;
10(1):87.
PMID: 30622252
Mutations in the ATM tumor suppressor gene confer hypersensitivity to DNA-damaging chemotherapeutic agents. To explore genetic resistance mechanisms, we performed genome-wide CRISPR-Cas9 screens in cells treated with the DNA topoisomerase...
7.
Dev H, Chiang T, Lescale C, de Krijger I, Martin A, Pilger D, et al.
Nat Cell Biol
. 2018 Jul;
20(8):954-965.
PMID: 30022119
BRCA1 deficiencies cause breast, ovarian, prostate and other cancers, and render tumours hypersensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. To understand the resistance mechanisms, we conducted whole-genome CRISPR-Cas9 synthetic-viability/resistance screens in...
8.
Franz A, Pirson P, Pilger D, Halder S, Achuthankutty D, Kashkar H, et al.
Nat Commun
. 2016 May;
7:11593.
PMID: 27186651
No abstract available.
9.
Franz A, Pirson P, Pilger D, Halder S, Achuthankutty D, Kashkar H, et al.
Nat Commun
. 2016 Feb;
7:10612.
PMID: 26842564
The coordinated activity of DNA replication factors is a highly dynamic process that involves ubiquitin-dependent regulation. In this context, the ubiquitin-directed ATPase CDC-48/p97 recently emerged as a key regulator of...