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Dolph L Hatfield

Explore the profile of Dolph L Hatfield including associated specialties, affiliations and a list of published articles. Areas
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Articles 146
Citations 5937
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Recent Articles
11.
Na J, Jung J, Bang J, Lu Q, Carlson B, Guo X, et al.
Free Radic Biol Med . 2018 May; 127:190-197. PMID: 29715549
Selenophosphate synthetase (SEPHS) synthesizes selenophosphate, the active selenium donor, using ATP and selenide as substrates. SEPHS was initially identified and isolated from bacteria and has been characterized in many eukaryotes...
12.
Carlson B, Lee B, Tsuji P, Copeland P, Schweizer U, Gladyshev V, et al.
Methods Mol Biol . 2017 Sep; 1661:43-60. PMID: 28917036
The selenocysteine (Sec) tRNA population consists of two isoforms that differ from each other by a single 2'-O-methylribosyl moiety at position 34 (Um34). These two isoforms, which are encoded in...
13.
Carlson B, Gupta N, Pinkerton M, Hatfield D, Copeland P
Translation (Austin) . 2017 Jul; 5(1):e1314240. PMID: 28702279
The tRNA for the 21st proteinogenic amino acid, selenocysteine, exists in mammalian cells as 2 isoforms differing by a single 2'-O-methylribosyl moiety at position 34 (Um34). These isoforms contain either...
14.
Fradejas-Villar N, Seeher S, Anderson C, Doengi M, Carlson B, Hatfield D, et al.
Nucleic Acids Res . 2016 Dec; 45(7):4094-4107. PMID: 27956496
Dual-assignment of codons as termination and elongation codons is used to expand the genetic code. In mammals, UGA can be reassigned to selenocysteine during translation of selenoproteins by a mechanism...
15.
Lobanov A, Heaphy S, Turanov A, Gerashchenko M, Pucciarelli S, Devaraj R, et al.
Nat Struct Mol Biol . 2016 Nov; 24(1):61-68. PMID: 27870834
The ribosome can change its reading frame during translation in a process known as programmed ribosomal frameshifting. These rare events are supported by complex mRNA signals. However, we found that...
16.
Gladyshev V, Arner E, Berry M, Brigelius-Flohe R, Bruford E, Burk R, et al.
J Biol Chem . 2016 Sep; 291(46):24036-24040. PMID: 27645994
The human genome contains 25 genes coding for selenocysteine-containing proteins (selenoproteins). These proteins are involved in a variety of functions, most notably redox homeostasis. Selenoprotein enzymes with known functions are...
17.
Carlson B, Tobe R, Yefremova E, Tsuji P, Hoffmann V, Schweizer U, et al.
Redox Biol . 2016 Jun; 9:22-31. PMID: 27262435
The selenoenzyme glutathione peroxidase 4 (Gpx4) is an essential mammalian glutathione peroxidase, which protects cells against detrimental lipid peroxidation and governs a novel form of regulated necrotic cell death, called...
18.
Tobe R, Carlson B, Huh J, Castro N, Xu X, Tsuji P, et al.
Biochem J . 2016 May; 473(14):2141-54. PMID: 27208177
Selenophosphate synthetase (SPS) was initially detected in bacteria and was shown to synthesize selenophosphate, the active selenium donor. However, mammals have two SPS paralogues, which are designated SPS1 and SPS2....
19.
Hatfield D
Antioxid Redox Signal . 2016 Mar; 25(1):1-9. PMID: 26984707
Professor Vadim N. Gladyshev is recognized here as a Redox Pioneer, because he has published an article on antioxidant/redox biology that has been cited more than 1000 times and 29...
20.
Tobe R, Carlson B, Tsuji P, Lee B, Gladyshev V, Hatfield D
Cancers (Basel) . 2015 Nov; 7(4):2262-76. PMID: 26569310
A common characteristic of many cancer cells is that they suffer from oxidative stress. They, therefore, require effective redox regulatory systems to combat the higher levels of reactive oxygen species...