Dmitri Tolkatchev
Overview
Explore the profile of Dmitri Tolkatchev including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
25
Citations
238
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Tolkatchev D, Smith Jr G, Kostyukova A
Methods Mol Biol
. 2023 Apr;
2652:405-437.
PMID: 37093489
Binding affinity of an individual binding site of an intrinsically disordered protein for its folded partner may be moderate. In such cases, a straightforward determination of the structure of the...
2.
Smith G, Tolkatchev D, Risi C, Little M, Gregorio C, Galkin V, et al.
Protein Sci
. 2022 Jun;
31(7):e4358.
PMID: 35762710
A transient increase in Ca concentration in sarcomeres is essential for their proper function. Ca drives striated muscle contraction via binding to the troponin complex of the thin filament to...
3.
Tolkatchev D, Gregorio C, Kostyukova A
FEBS J
. 2021 Jul;
289(20):6119-6131.
PMID: 34273242
Leiomodin is an important emerging regulator of thin filaments. As novel molecular, cellular, animal model, and human data accumulate, the mechanisms of its action become clearer. Structural studies played a...
4.
Tolkatchev D, Kuruba B, Smith Jr G, Swain K, Smith K, Moroz N, et al.
Protein Sci
. 2020 Nov;
30(2):423-437.
PMID: 33206408
Tropomodulins are a family of important regulators of actin dynamics at the pointed ends of actin filaments. Four isoforms of tropomodulin, Tmod1-Tmod4, are expressed in vertebrates. Binding of tropomodulin to...
5.
Tolkatchev D, Smith Jr G, Schultz L, Colpan M, Helms G, Cort J, et al.
PLoS Biol
. 2020 Sep;
18(9):e3000848.
PMID: 32898131
Improper lengths of actin-thin filaments are associated with altered contractile activity and lethal myopathies. Leiomodin, a member of the tropomodulin family of proteins, is critical in thin filament assembly and...
6.
Tolkatchev D, Smith Jr G, Kostyukova A
Prog Mol Biol Transl Sci
. 2019 Sep;
166:311-340.
PMID: 31521234
The role and utility of intrinsically disordered regions (IDRs) is reviewed for two groups of sarcomeric proteins, such as members of tropomodulin/leiomodin (Tmod/Lmod) protein homology group and myosin binding protein...
7.
Tolkatchev D, Elnatan D, Nogara L, Ly T, Naber N, Haak K, et al.
Arch Biochem Biophys
. 2018 Oct;
659:75-84.
PMID: 30287237
Piperine, an alkaloid from black pepper, was found to inhibit the super-relaxed state (SRX) of myosin in fast-twitch skeletal muscle fibers. In this work we report that the piperine molecule...
8.
Tolkatchev D
Methods Mol Biol
. 2018 Jun;
1806:65-80.
PMID: 29956269
Granulin (GRN) structural motif represents a ladderlike stack of β-hairpins reinforced with six parallel disulfide bridges. When GRNs are produced in a recombinant protein expression host (e.g., in bacteria) or...
9.
Tolkatchev D
Methods Mol Biol
. 2018 Jun;
1806:51-64.
PMID: 29956268
Generating milligram quantities of correctly folded granulin molecules with properly formed disulfide bonds and biologically relevant activities may represent a considerable challenge. Here I describe a protocol for obtaining well-folded...
10.
Ly T, Krieger I, Tolkatchev D, Krone C, Moural T, Samatey F, et al.
Protein Sci
. 2017 Nov;
27(2):498-508.
PMID: 29105867
The missense mutation R21H in striated muscle tropomyosin is associated with hypertrophic cardiomyopathy, a genetic cardiac disease and a leading cause of sudden cardiac death in young people. Tropomyosin adopts...