Divya Nandakumar
Overview
Explore the profile of Divya Nandakumar including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
785
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Recent Articles
11.
Nandakumar D, Patel S
Methods
. 2016 May;
108:65-78.
PMID: 27173619
Replicative helicases work closely with the replicative DNA polymerases to ensure that the genomic DNA is copied in a timely and error free manner. In the replisomes of prokaryotes, mitochondria,...
12.
Nandakumar D, Pandey M, Patel S
Elife
. 2015 May;
4.
PMID: 25970034
Leading strand DNA synthesis requires functional coupling between replicative helicase and DNA polymerase (DNAP) enzymes, but the structural and mechanistic basis of coupling is poorly understood. This study defines the...
13.
Nandakumar D, Patel S
Cell
. 2015 Feb;
160(5):809-811.
PMID: 25723158
DNA recombinases face the daunting task of locating and pairing up specific sequences among millions of base pairs in a genome, all within about an hour. Qi et al. show...
14.
Tang G, Nandakumar D, Bandwar R, Lee K, Roy R, Ha T, et al.
PLoS One
. 2014 Mar;
9(3):e91859.
PMID: 24651161
Abortive cycling is a universal feature of transcription initiation catalyzed by DNA-dependent RNA polymerases (RNAP). In bacteriophage T7 RNAP, mutation of proline 266 to leucine (P266L) in the C-linker region...
15.
Sen D, Nandakumar D, Tang G, Patel S
J Biol Chem
. 2012 Mar;
287(18):14545-56.
PMID: 22383523
TWINKLE is a nucleus-encoded human mitochondrial (mt)DNA helicase. Point mutations in TWINKLE are associated with heritable neuromuscular diseases characterized by deletions in the mtDNA. To understand the biochemical basis of...
16.
Patel S, Pandey M, Nandakumar D
Curr Opin Chem Biol
. 2011 Aug;
15(5):595-605.
PMID: 21865075
Helicases are molecular motor proteins that couple NTP hydrolysis to directional movement along nucleic acids. A class of helicases characterized by their ring-shaped hexameric structures translocate processively and unidirectionally along...