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Divya Murthy

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Articles 29
Citations 661
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Recent Articles
1.
Park J, Jung K, Jia D, Yang S, Attri K, Ahn S, et al.
Cell Rep Med . 2025 Feb; 6(2):101941. PMID: 39933530
The biguanide metformin attenuates mitochondrial oxidation and is proposed as an anti-cancer therapy. However, recent clinical studies suggest increased proliferation and fatty acid β-oxidation (FAO) in a subgroup of patients...
2.
Yaghjyan L, Heng Y, Baker G, Murthy D, Mahoney M, Rosner B, et al.
Br J Cancer . 2024 Jun; 131(2):325-333. PMID: 38849477
Background: We examined associations of CD44, CD24 and ALDH1A1 breast stem cell markers with mammographic breast density (MBD), a well-established breast cancer (BCa) risk factor. Methods: We included 218 cancer-free...
3.
Oh H, Yaghjyan L, Heng Y, Rosner B, Mahoney M, Murthy D, et al.
Cancer Epidemiol Biomarkers Prev . 2024 Apr; 33(7):933-943. PMID: 38652503
Background: According to the stem cell hypothesis, breast carcinogenesis may be related to the breast stem cell pool size. However, little is known about associations of breast cancer risk factors,...
4.
Murthy D, Attri K, Shukla S, Thakur R, Chaika N, He C, et al.
Nat Cell Biol . 2024 Apr; 26(5):840. PMID: 38641662
No abstract available.
5.
Yaghjyan L, Heng Y, Baker G, Bret-Mounet V, Murthy D, Mahoney M, et al.
Front Oncol . 2024 Apr; 14:1354094. PMID: 38577336
Background: We investigated the associations of reproductive factors known to influence breast cancer risk with the expression of breast stem cell markers CD44, CD24, and ALDH1A1 in benign breast biopsy...
6.
Murthy D, Attri K, Suresh V, Rajacharya G, Valenzuela C, Thakur R, et al.
Proc Natl Acad Sci U S A . 2024 Mar; 121(14):e2315509121. PMID: 38547055
Dysregulation of polyamine metabolism has been implicated in cancer initiation and progression; however, the mechanism of polyamine dysregulation in cancer is not fully understood. In this study, we investigated the...
7.
Murthy D, Attri K, Shukla S, Thakur R, Chaika N, He C, et al.
Nat Cell Biol . 2024 Mar; 26(4):613-627. PMID: 38429478
The ability of tumour cells to thrive in harsh microenvironments depends on the utilization of nutrients available in the milieu. Here we show that pancreatic cancer-associated fibroblasts (CAFs) regulate tumour...
8.
Murthy D, Dutta D, Attri K, Samanta T, Yang S, Jung K, et al.
Cancer Lett . 2024 Feb; 587:216724. PMID: 38373689
CD24 is a well-characterized breast cancer (BC) stem cell (BCSC) marker. Primary breast tumor cells having CD24-negativity together with CD44-positivity is known to maintain high metastatic potential. However, the functional...
9.
Yaghjyan L, Heng Y, Baker G, Murthy D, Mahoney M, Rosner B, et al.
Am J Cancer Res . 2024 Jan; 13(12):6280-6289. PMID: 38187066
We examined associations of stem cell markers CD44, CD24, and ALDH1A1 in benign breast biopsy samples with subsequent breast cancer (BCa) risk and explored if these associations were mediated by...
10.
He C, Wang D, Shukla S, Hu T, Thakur R, Fu X, et al.
Cancer Discov . 2023 Nov; 14(1):176-193. PMID: 37931287
Significance: The nutrient competition among the different tumor microenvironment components drives tumor growth, immune tolerance, and therapeutic resistance. PDAC cells demand a high amount of VB6, thus competitively causing NK-cell...