Dingyu Hu
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Explore the profile of Dingyu Hu including associated specialties, affiliations and a list of published articles.
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10
Citations
155
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Recent Articles
1.
Wang Y, Liu Z, Xu Z, Shao W, Hu D, Zhong H, et al.
Mol Biol Rep
. 2022 Jul;
49(11):10761-10773.
PMID: 35810239
Autophagy is a lysosomal degradation pathway that depends on various evolutionarily conserved autophagy-related genes (ATGs). Dysregulation of autophagy plays an important role in the occurrence and development of cancer. Chemotherapy,...
2.
Liu L, Li H, Hu D, Wang Y, Shao W, Zhong J, et al.
Mol Cancer
. 2022 Jan;
21(1):32.
PMID: 35090469
N6-methyladenosine (m6A) methylation, the most common form of internal RNA modification in eukaryotes, has gained increasing attention and become a hot research topic in recent years. M6A plays multifunctional roles...
3.
Hu D, Shao W, Liu L, Wang Y, Yuan S, Liu Z, et al.
Cancer Cell Int
. 2021 Dec;
21(1):653.
PMID: 34876130
MYB is often overexpressed in malignant tumors and plays a carcinogenic role in the initiation and development of cancer. Deletion of the MYB regulatory C-terminal domain may be a driving...
4.
Hu D, Yuan S, Zhong J, Liu Z, Wang Y, Liu L, et al.
Pharmacol Ther
. 2021 Feb;
223:107817.
PMID: 33587950
Cellular senescence constitutes a permanent state of cell cycle arrest in proliferative cells induced by different stresses. The exploration of tumor pathogenesis and therapies has been a research hotspot in...
5.
Xie H, Liu J, Yu M, Wang Y, Yao C, Yao S, et al.
Am J Chin Med
. 2013 Nov;
41(6):1377-92.
PMID: 24228607
The natural product Laetispicine ( N -isobutyl-(3,4-methylendioxyphenyl)-2E, 4E, 9E-undecatrienoamide), was isolated from the Piper laetispicum C. DC and screened, for its antidepressant activity and antinociceptive effects. Structure-functional activities of five...
6.
Fang G, Xue M, Su M, Hu D, Li Y, Xiong B, et al.
Bioorg Med Chem Lett
. 2012 Jun;
22(14):4540-5.
PMID: 22738629
The introduction of the multi-objective optimization has dramatically changed the virtual combinatorial library design, which can consider many objectives simultaneously, such as synthesis cost and drug-likeness, thus may increase positive...
7.
Du Y, Li Q, Xiong B, Hui X, Wang X, Feng Y, et al.
Bioorg Med Chem
. 2010 Jun;
18(12):4255-68.
PMID: 20510622
A novel class of non-steroidal progesterone receptor antagonists with aromatic beta-amino-ketone scaffold have been synthesized and characterized with high binding affinity and great selectivity for the cognate receptors. Among them,...
8.
Zhu Y, Xiao K, Ma L, Xiong B, Fu Y, Yu H, et al.
Bioorg Med Chem
. 2009 Jan;
17(4):1600-13.
PMID: 19162488
To explore novel effective drugs for the treatment of Alzheimer's disease (AD), a series of dual inhibitors of acetylcholineterase (AChE) and beta-secretase (BACE-1) were designed based on the multi-target-directed ligands...
9.
Meng T, Zhang Z, Hu D, Lin L, Ding J, Wang X, et al.
J Comb Chem
. 2007 Jul;
9(5):739-41.
PMID: 17602597
No abstract available.
10.
Xiao K, Li X, Li J, Ma L, Hu B, Yu H, et al.
Bioorg Med Chem
. 2006 Mar;
14(13):4535-51.
PMID: 16510290
With the aim of developing small molecular non-peptide beta-secretase (BACE) inhibitors, Leu*Ala hydroxyethylene (HE) was investigated as a scaffold to design and synthesize a series of compounds. Taking advantage of...