Dimitrios L Wagner
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Explore the profile of Dimitrios L Wagner including associated specialties, affiliations and a list of published articles.
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18
Citations
1059
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Recent Articles
1.
Du W, Noyan F, McCallion O, Drosdek V, Kath J, Glaser V, et al.
Mol Ther
. 2025 Feb;
33(3):997-1013.
PMID: 39905729
Adoptive transfer of antigen-specific regulatory T cells (Tregs) is a promising strategy to combat immunopathologies in transplantation and autoimmune diseases. However, their low frequency in peripheral blood poses challenges for...
2.
Kath J, Franke C, Drosdek V, Du W, Glaser V, Fuster-Garcia C, et al.
Blood
. 2024 Mar;
143(25):2599-2611.
PMID: 38493479
Chimeric antigen receptor (CAR)-redirected immune cells hold significant therapeutic potential for oncology, autoimmune diseases, transplant medicine, and infections. All approved CAR-T therapies rely on personalized manufacturing using undirected viral gene...
3.
Kath J, Franke C, Drosdek V, Du W, Glaser V, Fuster-Garcia C, et al.
bioRxiv
. 2023 Dec;
PMID: 38116030
Key Points: Integration of ζ-deficient CARs into ζ gene allows generation of functional TCR-ablated CAR-T cells for allogeneic off-the-shelf use ζ-editing platform allows CAR reprogramming of NK cells without affecting...
4.
Kath J, Du W, Martini S, Elsallab M, Franke C, Hartmann L, et al.
Blood Adv
. 2023 May;
7(15):4124-4134.
PMID: 37196643
Graft-versus-host disease (GVHD) is a major risk of the administration of allogeneic chimeric antigen receptor (CAR)-redirected T cells to patients who are HLA unmatched. Gene editing can be used to...
5.
Glaser V, Flugel C, Kath J, Du W, Drosdek V, Franke C, et al.
Genome Biol
. 2023 Apr;
24(1):89.
PMID: 37095570
Background: Multiple genetic modifications may be required to develop potent off-the-shelf chimeric antigen receptor (CAR) T cell therapies. Conventional CRISPR-Cas nucleases install sequence-specific DNA double-strand breaks (DSBs), enabling gene knock-out...
6.
Braun T, Pruene A, Darguzyte M, Vom Stein A, Nguyen P, Wagner D, et al.
Front Immunol
. 2023 Apr;
14:1086433.
PMID: 37033919
Introduction: The ubiquitous Epstein-Barr virus (EBV) is an oncogenic herpes virus associated with several human malignancies. EBV is an immune-evasive pathogen that promotes CD8 T cell exhaustion and dysregulates CD4...
7.
Flugel C, Majzner R, Krenciute G, Dotti G, Riddell S, Wagner D, et al.
Nat Rev Clin Oncol
. 2022 Nov;
20(1):49-62.
PMID: 36418477
Therapies with genetically modified T cells that express chimeric antigen receptors (CARs) specific for CD19 or B cell maturation antigen (BCMA) are approved to treat certain B cell malignancies. However,...
8.
Gottschalk I, Kolsch U, Wagner D, Kath J, Martini S, Kruger R, et al.
J Clin Immunol
. 2022 Nov;
43(2):421-439.
PMID: 36319802
Purpose: Besides their developmental and neurological phenotype, most patients with MECP2/IRAK1 duplication syndrome present with recurrent and severe infections, accompanied by strong inflammation. Respiratory infections are the most common cause...
9.
Wagner D, Koehl U, Chmielewski M, Scheid C, Stripecke R
Front Immunol
. 2022 Jul;
13:865424.
PMID: 35784280
T cells modified for expression of Chimeric Antigen Receptors (CARs) were the first gene-modified cell products approved for use in cancer immunotherapy. CAR-T cells engineered with gammaretroviral or lentiviral vectors...
10.
Kath J, Du W, Pruene A, Braun T, Thommandru B, Turk R, et al.
Mol Ther Methods Clin Dev
. 2022 May;
25:311-330.
PMID: 35573047
Chimeric antigen receptor (CAR) redirected T cells are potent therapeutic options against hematological malignancies. The current dominant manufacturing approach for CAR T cells depends on retroviral transduction. With the advent...