Dieter Waschbusch
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Explore the profile of Dieter Waschbusch including associated specialties, affiliations and a list of published articles.
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13
Citations
270
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Recent Articles
1.
Waschbusch D, Berndsen K, Lis P, Knebel A, Lam Y, Alessi D, et al.
EMBO Rep
. 2021 Sep;
22(11):e52675.
PMID: 34580980
LRRK2 serine/threonine kinase is associated with inherited Parkinson's disease. LRRK2 phosphorylates a subset of Rab GTPases within their switch 2 motif to control their interactions with effectors. Recent work has...
2.
Waschbusch D, Purlyte E, Khan A
Biophys J
. 2021 Apr;
120(9):1846-1855.
PMID: 33887226
Parkinson's-disease-associated LRRK2 is a multidomain Ser/Thr kinase that phosphorylates a subset of Rab GTPases to control their effector functions. Rab GTPases are the prime regulators of membrane trafficking in eukaryotic...
3.
Waschbusch D, Khan A
Traffic
. 2020 Sep;
21(11):712-719.
PMID: 32969543
Rab GTPases are master regulators of membrane trafficking in eukaryotic cells. Phosphorylation of Rab GTPases was characterized in the 1990s and there have been intermittent reports of its relevance to...
4.
Waschbusch D, Purlyte E, Pal P, McGrath E, Alessi D, Khan A
Structure
. 2020 Feb;
28(4):406-417.e6.
PMID: 32017888
Rab8a is associated with the dynamic regulation of membrane protrusions in polarized cells. Rab8a is one of several Rab GTPases that are substrates of leucine-rich repeat kinase 2 (LRRK2), a...
5.
McGrath E, Waschbusch D, Baker B, Khan A
Small GTPases
. 2019 Sep;
12(2):133-146.
PMID: 31552791
LRRK2 is a multi-domain Ser/Thr kinase that is associated with inherited and sporadic cases of Parkinson's disease. Many mutations linked to disease are associated within a central ROC-COR regulatory region...
6.
Waschbusch D, Hubel N, Ossendorf E, Lobbestael E, Baekelandt V, Lindsay A, et al.
PLoS One
. 2019 Jan;
14(1):e0208889.
PMID: 30640902
The Rab family of small GTPases regulate various aspects of cellular dynamics in eukaryotic cells. Membrane trafficking has emerged as central to the functions of leucine-rich repeat kinase 2 (LRRK2),...
7.
Madero-Perez J, Fdez E, Fernandez B, Lara Ordonez A, Blanca Ramirez M, Gomez-Suaga P, et al.
Mol Neurodegener
. 2018 Jan;
13(1):3.
PMID: 29357897
Background: Mutations in LRRK2 are a common genetic cause of Parkinson's disease (PD). LRRK2 interacts with and phosphorylates a subset of Rab proteins including Rab8a, a protein which has been...
8.
Waschbusch D, Michels H, Strassheim S, Ossendorf E, Kessler D, Gloeckner C, et al.
PLoS One
. 2014 Nov;
9(10):e111632.
PMID: 25360523
Leucine-rich repeat kinase 2 (LRRK2) is a multi-domain 280 kDa protein that is linked to Parkinson's disease (PD). Mutations especially in the GTPase and kinase domains of LRRK2 are the...
9.
Schluter K, Waschbusch D, Anft M, Hugging D, Kind S, Hanisch J, et al.
Eur J Cell Biol
. 2014 Jul;
93(5-6):194-204.
PMID: 25015719
Junction-mediating and regulatory protein (JMY) was originally identified as a transcriptional co-factor in the p53-response to DNA damage. Aside from this nuclear function, recent years have uncovered an additional function...
10.
Thyrock A, Ossendorf E, Stehling M, Kail M, Kurtz T, Pohlentz G, et al.
PLoS One
. 2013 Jun;
8(5):e64149.
PMID: 23737971
Small GTPases of the Rab family are important regulators of a large variety of different cellular functions such as membrane organization and vesicle trafficking. They have been shown to play...