Evy Lobbestael
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Explore the profile of Evy Lobbestael including associated specialties, affiliations and a list of published articles.
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35
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1353
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Recent Articles
1.
Kania E, Long J, McEwan D, Welkenhuyzen K, La Rovere R, Luyten T, et al.
Cell Death Dis
. 2023 Jul;
14(7):436.
PMID: 37454104
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common genetic cause of Parkinson's disease (PD), with growing importance also for Crohn's disease and cancer. LRRK2 is...
2.
Obergasteiger J, Castonguay A, Pizzi S, Magnabosco S, Frapporti G, Lobbestael E, et al.
NPJ Parkinsons Dis
. 2023 Mar;
9(1):44.
PMID: 36973269
In Parkinson's disease (PD) misfolded alpha-synuclein (aSyn) accumulates in the substantia nigra, where dopaminergic neurons are progressively lost. The mechanisms underlying aSyn pathology are still unclear, but they are hypothesized...
3.
Di Leva F, Filosi M, Oyston L, Silvestri E, Picard A, Lavdas A, et al.
Int J Mol Sci
. 2023 Feb;
24(3).
PMID: 36768321
Autosomal dominant mutations in the gene encoding α-synuclein () were the first to be linked with hereditary Parkinson's disease (PD). Duplication and triplication of has been observed in PD patients,...
4.
Drouyer M, Bolliger M, Lobbestael E, Van den Haute C, Emanuele M, Lefebvre R, et al.
Neurobiol Dis
. 2021 Jun;
157:105426.
PMID: 34144124
LRRK2 is a highly phosphorylated multidomain protein and mutations in the gene encoding LRRK2 are a major genetic determinant of Parkinson's disease (PD). Dephosphorylation at LRRK2's S910/S935/S955/S973 phosphosite cluster is...
5.
Si J, Van den Haute C, Lobbestael E, Martin S, van Veen S, Vangheluwe P, et al.
Int J Mol Sci
. 2021 Apr;
22(5).
PMID: 33799982
ATP13A2, a late endo-/lysosomal polyamine transporter, is implicated in a variety of neurodegenerative diseases, including Parkinson's disease and Kufor-Rakeb syndrome, an early-onset atypical form of parkinsonism. Loss-of-function mutations in ATP13A2...
6.
Van der Perren A, Cabezudo D, Gelders G, Peralta Ramos J, Van den Haute C, Baekelandt V, et al.
Neurotherapeutics
. 2021 Feb;
18(2):949-961.
PMID: 33594532
The development of disease-modifying therapies for Parkinson's disease is a major challenge which would be facilitated by a better understanding of the pathogenesis. Leucine-rich repeat kinase 2 (LRRK2) and α-synuclein...
7.
Iannotta L, Biosa A, Kluss J, Tombesi G, Kaganovich A, Cogo S, et al.
Cells
. 2020 Oct;
9(11).
PMID: 33105882
Mutations in LRRK2 cause familial Parkinson's disease and common variants increase disease risk. LRRK2 kinase activity and cellular localization are tightly regulated by phosphorylation of key residues, primarily Ser1292 and...
8.
Lee H, Lobbestael E, Vermeire S, Sabino J, Cleynen I
Gut
. 2020 Oct;
70(2):408-417.
PMID: 33067333
Inflammatory bowel disease and Parkinson's disease are chronic progressive disorders that mainly affect different organs: the gut and brain, respectively. Accumulating evidence has suggested a bidirectional link between gastrointestinal inflammation...
9.
Lobbestael E, Van den Haute C, Macchi F, Taymans J, Baekelandt V
Biosci Rep
. 2020 Sep;
40(10).
PMID: 32975566
Pathogenic mutations in the leucine-rich repeat kinase 2 (LRRK2) gene belong to the most common genetic causes of inherited Parkinson's disease (PD) and variations in its locus increase the risk...
10.
Volta M, Lewis P, Lobbestael E
Front Neurosci
. 2020 Aug;
14:741.
PMID: 32848540
No abstract available.