Didier Dulon
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Explore the profile of Didier Dulon including associated specialties, affiliations and a list of published articles.
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858
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Recent Articles
1.
Dulon D, de Monvel J, Plion B, Mallet A, Petit C, Condamine S, et al.
Prog Neurobiol
. 2024 Aug;
240:102658.
PMID: 39103114
Our understanding of how otoferlin, the major calcium sensor in inner hair cells (IHCs) synaptic transmission, contributes to the overall dynamics of synaptic vesicle (SV) trafficking remains limited. To address...
2.
Mendia C, Peineau T, Zamani M, Felgerolle C, Yahiaoui N, Christophersen N, et al.
Mol Ther
. 2024 Jan;
32(3):800-817.
PMID: 38243601
Hearing loss is a major health concern affecting millions of people worldwide with currently limited treatment options. In clarin-2-deficient Clrn2 mice, used here as a model of progressive hearing loss,...
3.
Jaffredo M, Duchamp O, Touya N, Bouleau Y, Dulon D, Devillard R, et al.
Hear Res
. 2023 Sep;
438:108880.
PMID: 37666034
Transtympanic administration is used clinically for the injection of gentamicin and/or corticosteroids. This atraumatic route is based on passive diffusion through the round window membrane (RWM). The main limitation of...
4.
Leclere J, Dulon D
Front Cell Neurosci
. 2023 Aug;
17:1197611.
PMID: 37538852
Humans have six members of the ferlin protein family: dysferlin, myoferlin, otoferlin, fer1L4, fer1L5, and fer1L6. These proteins share common features such as multiple Ca-binding C2 domains, FerA domains, and...
5.
Ferraguto C, Bouleau Y, Peineau T, Dulon D, Pietropaolo S
Int J Mol Sci
. 2023 Jul;
24(14).
PMID: 37511622
Hyperacusis, i.e., an increased sensitivity to sounds, is described in several neurodevelopmental disorders (NDDs), including Fragile X Syndrome (FXS). The mechanisms underlying hyperacusis in FXS are still largely unknown and...
6.
Calvet C, Peineau T, Benamer N, Cornille M, Lelli A, Plion B, et al.
iScience
. 2022 Dec;
25(12):105628.
PMID: 36483015
Hearing depends on fast and sustained calcium-dependent synaptic vesicle fusion at the ribbon synapses of cochlear inner hair cells (IHCs). The implication of the canonical neuronal SNARE complex in this...
7.
Peineau T, Belleudy S, Pietropaolo S, Bouleau Y, Dulon D
Front Aging Neurosci
. 2021 Nov;
13:756449.
PMID: 34733152
Age-related hidden hearing loss is often described as a cochlear synaptopathy that results from a progressive degeneration of the inner hair cell (IHC) ribbon synapses. The functional changes occurring at...
8.
Dunbar L, Patni P, Aguilar C, Mburu P, Corns L, Wells H, et al.
EMBO Mol Med
. 2019 Aug;
11(9):e10288.
PMID: 31448880
Hearing relies on mechanically gated ion channels present in the actin-rich stereocilia bundles at the apical surface of cochlear hair cells. Our knowledge of the mechanisms underlying the formation and...
9.
Tertrais M, Bouleau Y, Emptoz A, Belleudy S, Sutton R, Petit C, et al.
J Neurosci
. 2019 Mar;
39(18):3394-3411.
PMID: 30833506
Transmitter release at auditory inner hair cell (IHC) ribbon synapses involves exocytosis of glutamatergic vesicles during voltage activation of L-type Ca1.3 calcium channels. At these synapses, the fast and indefatigable...
10.
Vincent P, Cho S, Tertrais M, Bouleau Y, von Gersdorff H, Dulon D
Cell Rep
. 2018 Dec;
25(12):3451-3464.e3.
PMID: 30566869
A Ca current transient block (ITB) by protons occurs at some ribbon-type synapses after exocytosis, but this has not been observed at mammalian hair cells. Here we show that a...