Saaid Safieddine
Overview
Explore the profile of Saaid Safieddine including associated specialties, affiliations and a list of published articles.
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35
Citations
1488
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Recent Articles
1.
Underhill A, Webb S, Grandi F, Jeng J, de Monvel J, Plion B, et al.
Proc Natl Acad Sci U S A
. 2025 Jan;
122(1):e2414707122.
PMID: 39746042
Myosin-VIIA (MYO7A) is an unconventional myosin responsible for syndromic (Usher 1B) or nonsyndromic forms of deafness in humans when mutated. In the cochlea, MYO7A is expressed in hair cells, where...
2.
OConnor A, Amariutei A, Zanella A, Hool S, Carlton A, Kong F, et al.
JCI Insight
. 2024 Dec;
9(23).
PMID: 39641274
In the mammalian cochlea, sensory hair cells are crucial for the transduction of acoustic stimuli into electrical signals, which are then relayed to the central auditory pathway via spiral ganglion...
3.
Dulon D, de Monvel J, Plion B, Mallet A, Petit C, Condamine S, et al.
Prog Neurobiol
. 2024 Aug;
240:102658.
PMID: 39103114
Our understanding of how otoferlin, the major calcium sensor in inner hair cells (IHCs) synaptic transmission, contributes to the overall dynamics of synaptic vesicle (SV) trafficking remains limited. To address...
4.
Spinola C, de Monvel J, Safieddine S, Lahlou G, Etournay R
PLoS One
. 2024 Jul;
19(7):e0305742.
PMID: 39028743
In vivo gene delivery to tissues using adeno-associated vector (AAVs) has revolutionized the field of gene therapy. Yet, while sensorineural hearing loss is one of the most common sensory disorders...
5.
Lahlou G, Calvet C, Simon F, Michel V, Alciato L, Plion B, et al.
JCI Insight
. 2024 Jan;
9(3).
PMID: 38194286
Neonatal gene therapy has been shown to prevent inner ear dysfunction in mouse models of Usher syndrome type I (USH1), the most common genetic cause of combined deafness-blindness and vestibular...
6.
Amariutei A, Jeng J, Safieddine S, Marcotti W
R Soc Open Sci
. 2023 Jun;
10(6):230644.
PMID: 37325593
Hearing loss is the most common sensory deficit experienced by humans and represents one of the largest chronic health conditions worldwide. It is expected that around 10% of the world's...
7.
Petit C, Bonnet C, Safieddine S
Nat Rev Genet
. 2023 May;
24(10):665-686.
PMID: 37173518
Progress in deciphering the genetic architecture of human sensorineural hearing impairment (SNHI) or loss, and multidisciplinary studies of mouse models, have led to the elucidation of the molecular mechanisms underlying...
8.
Lahlou G, Calvet C, Giorgi M, Lecomte M, Safieddine S
J Clin Med
. 2023 Feb;
12(3).
PMID: 36769694
Hearing loss, the most common human sensory defect worldwide, is a major public health problem. About 70% of congenital forms and 25% of adult-onset forms of deafness are of genetic...
9.
Calvet C, Peineau T, Benamer N, Cornille M, Lelli A, Plion B, et al.
iScience
. 2022 Dec;
25(12):105628.
PMID: 36483015
Hearing depends on fast and sustained calcium-dependent synaptic vesicle fusion at the ribbon synapses of cochlear inner hair cells (IHCs). The implication of the canonical neuronal SNARE complex in this...
10.
Hardelin J, Safieddine S
Med Sci (Paris)
. 2020 Jan;
35(12):1213-1215.
PMID: 31903944
No abstract available.