Derek J Nancarrow
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Explore the profile of Derek J Nancarrow including associated specialties, affiliations and a list of published articles.
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28
Citations
534
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Recent Articles
11.
Heiden B, Patel N, Nancarrow D, Hermann M, Brown R, Orringer M, et al.
J Surg Res
. 2018 Nov;
232:621-628.
PMID: 30463782
Background: 18F-fluorodeoxyglucose positron emission tomography is an imaging modality critical to the diagnosis and staging of esophageal cancer. Despite this, the genetic abnormalities associated with increased 18F-fluorodeoxyglucose (FDG)-maximum standardized uptake...
12.
Feingold P, Surman D, Brown K, Xu Y, McDuffie L, Shukla V, et al.
Mol Cancer Ther
. 2018 Jun;
17(9):2013-2023.
PMID: 29934340
In 2017, an estimated 17,000 individuals were diagnosed with esophageal adenocarcinoma (EAC), and less than 20% will survive 5 years. Positron emission tomography avidity is indicative of high glucose utilization...
13.
Ferrer-Torres D, Nancarrow D, Kuick R, Thomas D, Nadal E, Lin J, et al.
Oncotarget
. 2016 Jul;
7(34):54867-54882.
PMID: 27363029
The current high mortality rate of esophageal adenocarcinoma (EAC) reflects frequent presentation at an advanced stage. Recent efforts utilizing fluorescent peptides have identified overexpressed cell surface targets for endoscopic detection...
14.
Myers A, Lin L, Nancarrow D, Wang Z, Ferrer-Torres D, Thomas D, et al.
Oncotarget
. 2015 Aug;
6(28):25897-916.
PMID: 26317790
Esophageal adenocarcinoma (EAC) patients commonly present with advanced stage disease and demonstrate resistance to therapy, with response rates below 40%. Understanding the molecular mechanisms of resistance is crucial for improvement...
15.
Lin J, Myers A, Wang Z, Nancarrow D, Ferrer-Torres D, Handlogten A, et al.
Oncotarget
. 2015 Jun;
6(26):22239-57.
PMID: 26068949
Esophageal adenocarcinoma (EAC) is often diagnosed at an advanced stage, thus understanding the molecular basis for EAC invasion and metastasis is critical. Here we report that SPP1/OPN was highly overexpressed...
16.
Bond C, Nancarrow D, Wockner L, Wallace L, Montgomery G, Leggett B, et al.
PLoS One
. 2014 Mar;
9(3):e91739.
PMID: 24651849
The BRAF (V600E) mutation in colorectal cancers that are microsatellite stable (MSS) confers a poor patient prognosis, whereas BRAF mutant microsatellite-unstable (MSI) colorectal cancers have an excellent prognosis. BRAF wild...
17.
Dutton-Regester K, Aoude L, Nancarrow D, Stark M, OConnor L, Lanagan C, et al.
Genes Chromosomes Cancer
. 2012 Jan;
51(5):452-61.
PMID: 22250051
High density SNP arrays can be used to identify DNA copy number changes in tumors such as homozygous deletions of tumor suppressor genes and focal amplifications of oncogenes. Illumina Human...
18.
Bonazzi V, Nancarrow D, Stark M, Moser R, Boyle G, Aoude L, et al.
PLoS One
. 2011 Oct;
6(10):e26121.
PMID: 22028813
Epigenetic regulation of tumor suppressor genes (TSGs) has been shown to play a central role in melanomagenesis. By integrating gene expression and methylation array analysis we identified novel candidate genes...
19.
Nancarrow D, Clouston A, Smithers B, Gotley D, Drew P, Watson D, et al.
PLoS One
. 2011 Aug;
6(7):e22513.
PMID: 21829465
Esophageal adenocarcinoma (EAC) has become a major concern in Western countries due to rapid rises in incidence coupled with very poor survival rates. One of the key risk factors for...
20.
Phillips W, Lord R, Nancarrow D, Watson D, Whiteman D
J Gastroenterol Hepatol
. 2010 Dec;
26(4):639-48.
PMID: 21166712
Barrett's esophagus is an acquired metaplastic abnormality in which the normal stratified squamous epithelium lining of the esophagus is replaced by an intestinal-like columnar epithelium. While in itself a benign...