Dennis Verzijl
Overview
Explore the profile of Dennis Verzijl including associated specialties, affiliations and a list of published articles.
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28
Citations
690
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Recent Articles
11.
van Loenen P, de Graaf C, Verzijl D, Leurs R, Rognan D, Peters S, et al.
Eur J Pharmacol
. 2011 Jun;
667(1-3):105-12.
PMID: 21663738
The sphingosine-1-phosphate type 1 (S1P(1)) receptor is a new target in the treatment of auto-immune diseases as evidenced by the recent approval of FTY720 (Fingolimod). The ligand-binding pocket of the...
12.
Wijtmans M, Verzijl D, Bergmans S, Lai M, Bosch L, Smit M, et al.
Bioorg Med Chem
. 2011 May;
19(11):3384-93.
PMID: 21570852
Small-molecule ligands for the CXCR3 chemokine receptor receive considerable attention as a means to interrogate the roles of CXCR3 in vitro and in vivo and/or to potentially treat various conditions...
13.
Verzijl D, Ijzerman A
Purinergic Signal
. 2011 May;
7(2):171-92.
PMID: 21544511
Adenosine receptors are plasma membrane proteins that transduce an extracellular signal into the interior of the cell. Basically every mammalian cell expresses at least one of the four adenosine receptor...
14.
van Doorn R, van Horssen J, Verzijl D, Witte M, Ronken E, van Het Hof B, et al.
Glia
. 2010 Jul;
58(12):1465-76.
PMID: 20648639
Sphingolipids are a class of biologically active lipids that have a role in multiple biological processes including inflammation. Sphingolipids exert their functions by direct signaling or through signaling by their...
15.
Verzijl D, Peters S, Alewijnse A
Mol Cells
. 2010 Feb;
29(2):99-104.
PMID: 20127285
Regulatory processes including receptor phosphorylation and intracellular trafficking, also referred to as receptor internalization, are important processes to terminate G protein-coupled receptor (GPCR) signaling. Compelling evidence now indicates that internalization...
16.
Wijtmans M, Verzijl D, van Dam C, Bosch L, Smit M, Leurs R, et al.
Bioorg Med Chem Lett
. 2009 Mar;
19(8):2252-7.
PMID: 19299127
A CXCR3 pocket capable of accommodating polycycloaliphatics was explored using a modular synthetic strategy. The systematic studies reveal that the tricyclic 2-adamantane and bicyclic (iso)bornyl group are efficiently recognized by...
17.
Wijtmans M, Verzijl D, Leurs R, de Esch I, Smit M
ChemMedChem
. 2008 Apr;
3(6):861-72.
PMID: 18442035
The CXCR3 chemokine receptor was first discovered in 1996 and has been shown to play an important role in several diseases, most of which are related to inflammation. This review...
18.
Verzijl D, Storelli S, Scholten D, Bosch L, Reinhart T, Streblow D, et al.
J Pharmacol Exp Ther
. 2008 Feb;
325(2):544-55.
PMID: 18270317
The chemokine receptor CXCR3 is involved in various inflammatory diseases, such as rheumatoid arthritis, multiple sclerosis, psoriasis, and allograft rejection in transplantation patients. The CXCR3 ligands CXCL9, CXCL10, and CXCL11...
19.
Storelli S, Verzijl D, Al-Badie J, Elders N, Bosch L, Timmerman H, et al.
Arch Pharm (Weinheim)
. 2007 Jun;
340(6):281-91.
PMID: 17562560
CXC chemokine receptor-3 (CXCR3) is a G-protein coupled receptor (GPCR) predominantly expressed on activated T lymphocytes that promote Th1 responses. Previously, we described the 3H-quinazolin-4-one containing VUF 5834 (decanoic acid...
20.
Verzijl D, Pardo L, van Dijk M, Gruijthuijsen Y, Jongejan A, Timmerman H, et al.
J Biol Chem
. 2006 Sep;
281(46):35327-35.
PMID: 16997914
The constitutively active G-protein-coupled receptor and viral oncogene ORF74, encoded by Kaposi sarcoma-associated herpesvirus (human herpesvirus 8), binds a broad range of chemokines, including CXCL1 (agonist), CXCL8 (neutral ligand), and...