Dennis Madsen
Overview
Explore the profile of Dennis Madsen including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
542
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0
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Recent Articles
1.
Kubrak O, Jorgensen A, Koyama T, Lassen M, Nagy S, Hald J, et al.
Nat Commun
. 2024 Jul;
15(1):6126.
PMID: 39033139
Obesity impairs tissue insulin sensitivity and signaling, promoting type-2 diabetes. Although improving insulin signaling is key to reversing diabetes, the multi-organ mechanisms regulating this process are poorly defined. Here, we...
2.
Teufel F, Refsgaard J, Madsen C, Stahlhut C, Gronborg M, Winther O, et al.
Bioinformatics
. 2023 Oct;
39(10).
PMID: 37812217
Motivation: Peptides are ubiquitous throughout life and involved in a wide range of biological processes, ranging from neural signaling in higher organisms to antimicrobial peptides in bacteria. Many peptides are...
3.
Teufel F, Refsgaard J, Kasimova M, Deibler K, Madsen C, Stahlhut C, et al.
J Chem Inf Model
. 2023 Apr;
63(9):2651-2655.
PMID: 37092865
Many endogenous peptides rely on signaling pathways to exert their function, but identifying their cognate receptors remains a challenging problem. We investigate the use of AlphaFold-Multimer complex structure prediction together...
4.
Hansson L, Hansen R, Pletscher-Frankild S, Berzins R, Hansen D, Madsen D, et al.
PLoS One
. 2020 Jun;
15(6):e0233956.
PMID: 32542027
Background: Surveying the scientific literature is an important part of early drug discovery; and with the ever-increasing amount of biomedical publications it is imperative to focus on the most interesting...
5.
Tsonkova V, Sand F, Wolf X, Grunnet L, Ringgaard A, Ingvorsen C, et al.
Mol Metab
. 2018 Jan;
8:144-157.
PMID: 29307512
Objective: To characterize the EndoC-βH1 cell line as a model for human beta cells and evaluate its beta cell functionality, focusing on insulin secretion, proliferation, apoptosis and ER stress, with...
6.
Yang W, Padkjaer S, Wang J, Sun Z, Shan B, Yang L, et al.
J Biotechnol
. 2017 Sep;
260:18-30.
PMID: 28867483
Interactions between protein ligands and receptors play crucial roles in cell-cell signalling. Most of the human cell surface receptors have been identified in the post-Human Genome Project era but many...
7.
Yang L, Chang C, Sun Z, Madsen D, Zhu H, Padkjaer S, et al.
Nat Med
. 2017 Aug;
23(10):1158-1166.
PMID: 28846099
Growth differentiation factor 15 (GDF15; also known as MIC-1) is a divergent member of the TGF-β superfamily and is associated with body-weight regulation in humans and rodents. However, the cognate...
8.
The existence of multiple conformers of interleukin-21 directs engineering of a superpotent analogue
Bondensgaard K, Breinholt J, Madsen D, Omkvist D, Kang L, Worsaae A, et al.
J Biol Chem
. 2007 Jun;
282(32):23326-36.
PMID: 17565991
The high resolution three-dimensional structure of human interleukin (hIL)-21 has been resolved by heteronuclear NMR spectroscopy. Overall, the hIL-21 structure is dominated by a well defined central four-helical bundle, arranged...
9.
Petri A, Ahnfelt-Ronne J, Frederiksen K, Edwards D, Madsen D, Serup P, et al.
J Mol Endocrinol
. 2006 Oct;
37(2):301-16.
PMID: 17032746
To understand the molecular mechanisms regulating pancreatic endocrine development and function, pancreatic gene expression was compared between Ngn3-deficient mice and littermate controls on embryonic days 13 and 15. Microarray analysis...
10.
Skovgaard M, Kodra J, Gram D, Knudsen S, Madsen D, Liberles D
J Mol Biol
. 2006 Sep;
363(5):977-88.
PMID: 16989858
Glucagon-like peptide-1 (GLP-1) is an incretin hormone with therapeutic potential for type 2 diabetes. A variety of GLP-1 sequences are known from amphibian species, and some of these have been...