Demetrios T Braddock
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Explore the profile of Demetrios T Braddock including associated specialties, affiliations and a list of published articles.
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37
Citations
1666
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Recent Articles
1.
Kato H, Ishihara Y, Ohata Y, Irie K, Watanabe S, Kimura S, et al.
J Endocr Soc
. 2024 Nov;
8(12):bvae184.
PMID: 39498416
Context: Causative factors for ectopic ossifications in X-linked hypophosphatemia (XLH) remain to be elucidated. Objective: This work aimed to investigate the genotype-phenotype correlations between the phosphate-regulating endopeptidase homologue, X-linked gene...
2.
Jacobs I, Obiri-Yeboah D, Stabach P, Braddock D, Li Q
Mol Ther
. 2024 Sep;
32(11):3815-3820.
PMID: 39342427
Pseudoxanthoma elasticum (PXE) is a genetic multisystem ectopic calcification disorder caused by inactivating mutations in the ABCC6 gene encoding ABCC6, a hepatic efflux transporter. ABCC6-mediated ATP secretion by the liver...
3.
Stabach P, Sims D, Gomez-Banuelos E, Zehentmeier S, Dammen-Brower K, Bernhisel A, et al.
JCI Insight
. 2024 Jun;
9(14).
PMID: 38888971
A defining feature of systemic lupus erythematosus (SLE) is loss of tolerance to self-DNA, and deficiency of DNASE1L3, the main enzyme responsible for chromatin degradation in blood, is also associated...
4.
Ansh A, Stabach P, Ciccone C, Cao W, De La Cruz E, Sabbagh Y, et al.
Bone
. 2024 May;
186:117136.
PMID: 38806089
Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) codes for a type 2 transmembrane glycoprotein which hydrolyzes extracellular phosphoanhydrides into bio-active molecules that regulate, inter alia, ectopic mineralization, bone formation, vascular endothelial proliferation, and...
5.
Ferreira C, Carpenter T, Braddock D
Annu Rev Pathol
. 2023 Oct;
19:507-540.
PMID: 37871131
The enzyme ectonucleotide pyrophosphatase/phosphodiesterase 1 () codes for a type 2 transmembrane glycoprotein that hydrolyzes extracellular ATP to generate pyrophosphate (PP) and adenosine monophosphate, thereby contributing to downstream purinergic signaling...
6.
Kato H, Braddock D, Ito N
Curr Osteoporos Rep
. 2023 Aug;
21(5):552-566.
PMID: 37530996
Purpose Of Review: The study aims to provide updated information on the genetic factors associated with the diagnoses 'Diffuse Idiopathic Skeletal Hyperostosis' (DISH), 'Ossification of the Posterior Longitudinal Ligament' (OPLL),...
7.
Murtada S, Mikush N, Wang M, Ren P, Kawamura Y, Ramachandra A, et al.
Elife
. 2023 Mar;
12.
PMID: 36930696
Clinical trials have demonstrated that lonafarnib, a farnesyltransferase inhibitor, extends the lifespan in patients afflicted by Hutchinson-Gilford progeria syndrome, a devastating condition that accelerates many characteristics of aging and results...
8.
Theng E, Brewer C, Oheim R, Zalewski C, King K, Delsmann M, et al.
Orphanet J Rare Dis
. 2022 Jul;
17(1):273.
PMID: 35854274
Background And Importance: Hearing loss (HL) has been sporadically described, but not well characterized, in Generalized Arterial Calcification of Infancy (GACI), a rare disease in which pathological calcification typically presents...
9.
Zimmerman K, Liu X, von Kroge S, Stabach P, Lester E, Chu E, et al.
J Bone Miner Res
. 2022 Jul;
37(9):1733-1749.
PMID: 35773783
Biallelic ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) deficiency induces vascular/soft tissue calcifications in generalized arterial calcification of infancy (GACI), and low bone mass with phosphate-wasting rickets in GACI survivors (autosomal hypophosphatemic rickets...
10.
Dammen-Brower K, Epler P, Zhu S, Bernstein Z, Stabach P, Braddock D, et al.
Front Chem
. 2022 May;
10:863118.
PMID: 35494652
Almost all therapeutic proteins are glycosylated, with the carbohydrate component playing a long-established, substantial role in the safety and pharmacokinetic properties of this dominant category of drugs. In the past...