Demetrios T Braddock
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Explore the profile of Demetrios T Braddock including associated specialties, affiliations and a list of published articles.
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37
Citations
1666
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Recent Articles
11.
Kato H, Ansh A, Lester E, Kinoshita Y, Hidaka N, Hoshino Y, et al.
J Bone Miner Res
. 2022 Mar;
37(6):1125-1135.
PMID: 35340077
Homozygous ENPP1 mutations are associated with autosomal recessive hypophosphatemic rickets type 2 (ARHR2), severe ossification of the spinal ligaments, and generalized arterial calcification of infancy type 1. There are a...
12.
Ferreira C, Ansh A, Nester C, OBrien C, Stabach P, Murtada S, et al.
J Bone Miner Res
. 2021 Dec;
37(3):494-504.
PMID: 34882836
Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) deficiency leads to cardiovascular calcification in infancy, fibroblast growth factor 23 (FGF23)-mediated hypophosphatemic rickets in childhood, and osteomalacia in adulthood. Excessive enthesis mineralization and cervical spine...
13.
Li S, Yokota T, Wang P, Hoeve J, Ma F, Le T, et al.
J Clin Invest
. 2021 Nov;
132(2).
PMID: 34813507
Various populations of cells are recruited to the heart after cardiac injury, but little is known about whether cardiomyocytes directly regulate heart repair. Using a murine model of ischemic cardiac...
14.
Kaushik Tiwari M, Colon-Rios D, Tumu H, Liu Y, Quijano E, Krysztofiak A, et al.
Nat Biotechnol
. 2021 Oct;
40(3):325-334.
PMID: 34711990
Gene amplification drives oncogenesis in a broad spectrum of cancers. A number of drugs have been developed to inhibit the protein products of amplified driver genes, but their clinical efficacy...
15.
Ferreira C, Kavanagh D, Oheim R, Zimmerman K, Sturznickel J, Li X, et al.
J Bone Miner Res
. 2021 Jan;
36(5):942-955.
PMID: 33465815
Inactivating mutations in human ecto-nucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) may result in early-onset osteoporosis (EOOP) in haploinsufficiency and autosomal recessive hypophosphatemic rickets (ARHR2) in homozygous deficiency. ARHR2 patients are frequently treated with...
16.
Hsiao H, Crichlow G, Murphy J, Folta-Stogniew E, Lolis E, Braddock D
PLoS One
. 2020 Nov;
15(11):e0242725.
PMID: 33253191
Pre-mRNA splicing is critical for achieving required amounts of a transcript at a given time and for regulating production of encoded protein. A given pre-mRNA may be spliced in many...
17.
Stabach P, Zimmerman K, Adame A, Kavanagh D, Saeui C, Agatemor C, et al.
Clin Transl Sci
. 2020 Oct;
14(1):362-372.
PMID: 33064927
Enzyme replacement with ectonucleotide pyrophosphatase phospodiesterase-1 (ENPP1) eliminates mortality in a murine model of the lethal calcification disorder generalized arterial calcification of infancy. We used protein engineering, glycan optimization, and...
18.
Maulding N, Kavanagh D, Zimmerman K, Coppola G, Carpenter T, Jue N, et al.
Bone
. 2020 Sep;
142:115656.
PMID: 32980560
Ectonucleotide phosphatase/phosphodiesterase 1 (ENPP1) deficiency results in either lethal arterial calcifications ('Generalized Arterial Calcification of Infancy' - GACI), phosphate wasting rickets ('Autosomal Recessive Hypophosphatemic Rickets type 2' - ARHR2), early...
19.
Schlesinger P, Braddock D, Larrouture Q, Ray E, Riazanski V, Nelson D, et al.
Bone
. 2020 Aug;
141:115621.
PMID: 32858255
Three physiologically mineralizing tissues - teeth, cartilage and bone - have critical common elements and important evolutionary relationships. Phylogenetically the most ancient densely mineralized tissue is teeth. In jawless fishes...
20.
Malik S, Lim J, Slack F, Braddock D, Bahal R
J Control Release
. 2020 Aug;
327:406-419.
PMID: 32835710
Selective inhibition of microRNAs (miRNAs) offers a new avenue for cancer therapeutics. While most of the current anti-miRNA (antimiR) reagents target full length miRNAs, here we investigate novel nanoparticle-delivered short...