Delsi Altenhofen
Overview
Explore the profile of Delsi Altenhofen including associated specialties, affiliations and a list of published articles.
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15
Citations
112
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Recent Articles
1.
Turewicz M, Skagen C, Hartwig S, Majda S, Thedinga K, Herwig R, et al.
Nat Commun
. 2025 Feb;
16(1):1570.
PMID: 39939313
Insulin is a pleiotropic hormone that elicits its metabolic and mitogenic actions through numerous rapid and reversible protein phosphorylations. The temporal regulation of insulin's intracellular signaling cascade is highly complex...
2.
Bodis K, Breuer S, Crepzia-Pevzner A, Zaharia O, Schon M, Saatmann N, et al.
Diabetes Obes Metab
. 2023 Oct;
26(1):339-350.
PMID: 37869933
Aims: Exercise training induces white adipose tissue (WAT) beiging and improves glucose homeostasis and mitochondrial function in rodents. This could be relevant for type 2 diabetes in humans, but the...
3.
Altenhofen D, Khuong J, Kuhn T, Lebek S, Gorigk S, Kaiser K, et al.
Int J Mol Sci
. 2023 Jan;
24(1).
PMID: 36614300
Type 2 diabetes (T2D) represents a multifactorial metabolic disease with a strong genetic predisposition. Despite elaborate efforts in identifying the genetic variants determining individual susceptibility towards T2D, the majority of...
4.
Kuhn T, Kaiser K, Lebek S, Altenhofen D, Knebel B, Herwig R, et al.
Hum Mol Genet
. 2022 Jul;
31(23):4019-4033.
PMID: 35796564
To nominate novel disease genes for obesity and type 2 diabetes (T2D), we recently generated two mouse backcross populations of the T2D-susceptible New Zealand Obese (NZO/HI) mouse strain and two...
5.
Gorigk S, Ouwens D, Kuhn T, Altenhofen D, Binsch C, Damen M, et al.
Biochim Biophys Acta Mol Cell Biol Lipids
. 2022 Apr;
1867(6):159153.
PMID: 35367353
Changes in intracellular CoA levels are known to contribute to the development of non-alcoholic fatty liver disease (NAFLD) in type 2 diabetes (T2D) in human and rodents. However, the underlying...
6.
Rehman S, Schallschmidt T, Rasche A, Knebel B, Stermann T, Altenhofen D, et al.
Mamm Genome
. 2021 Apr;
32(3):153-172.
PMID: 33880624
Type 2 diabetes (T2D) has a strong genetic component. Most of the gene variants driving the pathogenesis of T2D seem to target pancreatic β-cell function. To identify novel gene variants...
7.
Klymenko O, Brecklinghaus T, Dille M, Springer C, de Wendt C, Altenhofen D, et al.
Mol Metab
. 2020 Aug;
42:101062.
PMID: 32771698
Objective: Physical exercise training is associated with increased glucose uptake in skeletal muscle and improved glycemic control. HDAC5, a class IIa histone deacetylase, has been shown to regulate transcription of...
8.
Ardestani A, Li S, Annamalai K, Lupse B, Geravandi S, Dobrowolski A, et al.
Nat Commun
. 2019 Nov;
10(1):5015.
PMID: 31676778
The loss of functional insulin-producing β-cells is a hallmark of diabetes. Mammalian sterile 20-like kinase 1 (MST1) is a key regulator of pancreatic β-cell death and dysfunction; its deficiency restores...
9.
Schallschmidt T, Lebek S, Altenhofen D, Damen M, Schulte Y, Knebel B, et al.
Genetics
. 2018 Oct;
210(4):1527-1542.
PMID: 30341086
To identify novel disease genes for type 2 diabetes (T2D) we generated two backcross populations of obese and diabetes-susceptible New Zealand Obese (NZO/HI) mice with the two lean mouse strains...
10.
Vogel H, Kamitz A, Hallahan N, Lebek S, Schallschmidt T, Jonas W, et al.
Hum Mol Genet
. 2018 Jun;
27(17):3099-3112.
PMID: 29893858
To explore the genetic determinants of obesity and Type 2 diabetes (T2D), the German Center for Diabetes Research (DZD) conducted crossbreedings of the obese and diabetes-prone New Zealand Obese mouse...