Deepankar Gahloth
Overview
Explore the profile of Deepankar Gahloth including associated specialties, affiliations and a list of published articles.
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14
Citations
150
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Recent Articles
1.
Mysko C, Landi S, Purssell H, Allen A, Prince M, Lindsay G, et al.
BJC Rep
. 2025 Mar;
3(1):13.
PMID: 40033086
Background: Hepatocellular carcinoma (HCC) remains a deadly cancer in the UK despite advancements in curative therapies. Societal conditions and health inequalities influence the development of chronic liver disease and outcomes...
2.
Gahloth D, Fisher K, Marshall S, Leys D
J Biol Chem
. 2024 Jan;
300(2):105653.
PMID: 38224946
The UbiD enzyme family of prenylated flavin (prFMN)-dependent reversible decarboxylases is near ubiquitously present in microbes. For some UbiD family members, enzyme activation through prFMNH binding and subsequent oxidative maturation...
3.
Gahloth D, Fisher K, Payne K, Cliff M, Levy C, Leys D
J Biol Chem
. 2022 Feb;
298(4):101771.
PMID: 35218772
The ubiquitous UbiD family of reversible decarboxylases is implicated in a wide range of microbial processes and depends on the prenylated flavin mononucleotide cofactor for catalysis. However, only a handful...
4.
Aleku G, Saaret A, Bradshaw-Allen R, Derrington S, Titchiner G, Gostimskaya I, et al.
Nat Chem Biol
. 2020 Jul;
16(11):1255-1260.
PMID: 32719558
The direct C-H carboxylation of aromatic compounds is an attractive route to the corresponding carboxylic acids, but remains challenging under mild conditions. It has been proposed that the first step...
5.
Gahloth D, Aleku G, Leys D
J Biotechnol
. 2019 Nov;
307:107-113.
PMID: 31689469
Carboxylic acid reductase (CAR) enzymes are large multi-domain proteins that catalyse the ATP- and NADPH-dependent reduction of wide range of acids to the corresponding aldehydes. This particular reaction is of...
6.
Marshall S, Payne K, Fisher K, Gahloth D, Bailey S, Balaikaite A, et al.
Methods Enzymol
. 2019 May;
620:489-508.
PMID: 31072499
The recent discovery of the prenylated FMN (prFMN) cofactor has led to a renewed interest in the prFMN-dependent UbiD family of enzymes. The latter catalyses the reversible decarboxylation of alpha-beta...
7.
Galman J, Gahloth D, Parmeggiani F, Slabu I, Leys D, Turner N
Front Bioeng Biotechnol
. 2019 Jan;
6:205.
PMID: 30622946
The reductive amination of prochiral ketones using biocatalysts has been of great interest to the pharmaceutical industry in the last decade for integrating novel strategies in the production of chiral...
8.
Gahloth D, Heaven G, Jowitt T, Mould A, Bella J, Baldock C, et al.
Sci Rep
. 2017 Aug;
7(1):9151.
PMID: 28831121
HD-PTP is a tumour suppressor phosphatase that controls endocytosis, down-regulation of mitogenic receptors and cell migration. Central to its role is the specific recruitment of critical endosomal sorting complexes required...
9.
Gahloth D, Dunstan M, Quaglia D, Klumbys E, Lockhart-Cairns M, Hill A, et al.
Nat Chem Biol
. 2017 Jul;
13(9):975-981.
PMID: 28719588
Carboxylic acid reductase (CAR) catalyzes the ATP- and NADPH-dependent reduction of carboxylic acids to the corresponding aldehydes. The enzyme is related to the nonribosomal peptide synthetases, consisting of an adenylation...
10.
Gahloth D, Levy C, Walker L, Wunderley L, Mould A, Taylor S, et al.
Structure
. 2017 Jun;
25(7):1011-1024.e4.
PMID: 28602823
SARA and endofin are endosomal adaptor proteins that drive Smad phosphorylation by ligand-activated transforming growth factor β/bone morphogenetic protein (TGFβ/BMP) receptors. We show in this study that SARA and endofin...