Purushotham Selvakumar
Overview
Explore the profile of Purushotham Selvakumar including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
87
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Recent Articles
1.
Strauss A, Gonzalez-Hernandez A, Lee J, Abreu N, Selvakumar P, Salas-Estrada L, et al.
Nat Commun
. 2024 Aug;
15(1):6498.
PMID: 39090128
The metabotropic glutamate receptors (mGluRs) are neuromodulatory family C G protein coupled receptors which assemble as dimers and allosterically couple extracellular ligand binding domains (LBDs) to transmembrane domains (TMDs) to...
2.
Strauss A, Gonzalez-Hernandez A, Lee J, Abreu N, Selvakumar P, Salas-Estrada L, et al.
bioRxiv
. 2023 Aug;
PMID: 37645747
Highlights: -Agonists and PAMs drive mGluR activation, desensitization, and endocytosis-PAMs are desensitization-biased and synergistic with agonists-Four combinatorial ligand conditions reveal an ensemble of full-length mGluR structures with novel interfaces-Activation and...
3.
Selvakumar P, Fernandez-Marino A, Khanra N, He C, Paquette A, Wang B, et al.
Nat Commun
. 2022 Jul;
13(1):3854.
PMID: 35788586
The Kv1.3 potassium channel is expressed abundantly on activated T cells and mediates the cellular immune response. This role has made the channel a target for therapeutic immunomodulation to block...
4.
Selvakumar P, Lee J, Khanra N, He C, Munguba H, Kiese L, et al.
Cell Rep
. 2021 Oct;
37(4):109891.
PMID: 34706237
The kainate receptors (KARs) are members of the ionotropic glutamate receptor family and assemble into tetramers from a pool of five subunit types (GluK1-5). Each subunit confers distinct functional properties...
5.
Sharma N, Selvakumar P, Saini G, Warghane A, Ghosh D, Kumar Sharma A
Biochim Biophys Acta
. 2016 Aug;
1864(12):1649-1657.
PMID: 27570147
A periplasmic solute binding protein from second of the two gene clusters of Znu system in CLA (CLas-ZnuA2) belong to Cluster A1 family of solute binding proteins (SBPs). The crystal...
6.
Singh A, Selvakumar P, Saraswat A, Tomar P, Mishra M, Singh P, et al.
Protein Pept Lett
. 2015 May;
22(8):750-61.
PMID: 26021386
A ~56 kDa protein having hemagglutination activity was purified and characterized from the Murraya paniculata seeds. The gel electrophoresis studies demonstrated that protein is primarily of two different subunits, molecular...
7.
Sharma N, Selvakumar P, Bhose S, Ghosh D, Kumar P, Kumar Sharma A
J Struct Biol
. 2015 Feb;
189(3):184-94.
PMID: 25641618
The Znu system, a member of ABC transporter family, is critical for survival and pathogenesis of Candidatus Liberibacter asiaticus (CLA). Two homologues of this system have been identified in CLA....
8.
Tomar P, Chaudhary N, Priyadarshi P, Mishra P, Gahloth D, Patel G, et al.
Appl Biochem Biotechnol
. 2014 Aug;
174(2):471-82.
PMID: 25080380
The present study reports the characterisation of a novel ~12-kDa heterodimeric protein, designated as putrin, from the seeds of Putranjiva roxburghii. The purification of putrin to homogeneity was accomplished using...
9.
Tomar P, Nikhil K, Singh A, Selvakumar P, Roy P, Kumar Sharma A
Biochem Biophys Res Commun
. 2014 May;
448(4):349-54.
PMID: 24814706
The plant 2S albumins exhibit a spectrum of biotechnologically exploitable functions. Among them, pumpkin 2S albumin has been shown to possess RNase and cell-free translational inhibitory activities. The present study...
10.
Selvakumar P, Sharma N, Tomar P, Kumar P, Kumar Sharma A
Proteins
. 2013 Nov;
82(5):830-40.
PMID: 24265134
Murraya koenigii miraculin-like protein (MKMLP) gradually precipitates below pH 7.5. Here, we explore the basis for this aggregation by identifying the aggregation-prone regions via comparative analysis of crystal structures acquired...