Deepak A Deshpande
Overview
Explore the profile of Deepak A Deshpande including associated specialties, affiliations and a list of published articles.
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Articles
87
Citations
2017
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Recent Articles
11.
Deshpande D, Penn R
Am J Respir Cell Mol Biol
. 2023 Sep;
69(6):605-607.
PMID: 37672671
No abstract available.
12.
Hernandez-Lara M, Yadav S, Conaway Jr S, Shah S, Penn R, Deshpande D
Respir Res
. 2023 Jun;
24(1):155.
PMID: 37301818
Background: Diacylglycerol kinase (DGK) regulates intracellular signaling and functions by converting diacylglycerol (DAG) into phosphatidic acid. We previously demonstrated that DGK inhibition attenuates airway smooth muscle (ASM) cell proliferation, however,...
13.
Shah S, Lind C, De Pascali F, Penn R, MacKerell Jr A, Deshpande D
Proc Natl Acad Sci U S A
. 2022 Nov;
119(49):e2214024119.
PMID: 36449547
Activation of β-adrenoceptors (βARs) causes airway smooth muscle (ASM) relaxation and bronchodilation, and βAR agonists (β-agonists) are front-line treatments for asthma and other obstructive lung diseases. However, the therapeutic efficacy...
14.
Hernandez-Lara M, Yadav S, Shah S, Okumura M, Yokoyama Y, Penn R, et al.
Int J Mol Sci
. 2022 Oct;
23(19).
PMID: 36233170
Airway remodeling in asthma involves the hyperproliferation of airway smooth muscle (ASM) cells. However, the molecular signals that regulate ASM growth are not completely understood. Gq-coupled G protein-coupled receptor and...
15.
Deshpande D, Penn R
Trends Mol Med
. 2022 Sep;
28(11):900-901.
PMID: 36109317
Over three decades of research have provided thorough insights into G protein-coupled receptor (GPCR) regulation. In a recent issue of Molecular Cell, Fonseca et al. identified a previously overlooked desensitization...
16.
Shah S, Nayak A, Sharma P, Villalba D, Addya S, Huang W, et al.
Am J Respir Cell Mol Biol
. 2022 Sep;
68(1):23-38.
PMID: 36067041
ERK1/2 (extracellular signal-regulated kinases 1 and 2) regulate the activity of various transcription factors that contribute to asthma pathogenesis. Although an attractive drug target, broadly inhibiting ERK1/2 is challenging because...
17.
Tompkins E, Mimic B, Cuevas-Mora K, Schorsch H, Shah S, Deshpande D, et al.
Am J Respir Cell Mol Biol
. 2022 Aug;
67(5):550-561.
PMID: 35944139
G protein-coupled receptors (GPCRs) not only are turned on or off to control canonical G protein signaling but also may be fine-tuned to promote qualitative/biased signaling. Qualitative signaling by M3...
18.
Defnet A, Shah S, Huang W, Shapiro P, Deshpande D, Kane M
FASEB J
. 2021 Nov;
35(12):e22016.
PMID: 34784434
Vitamin A deficiency has been shown to exacerbate allergic asthma. Previous studies have postulated that retinoic acid (RA), an active metabolite of vitamin A and high-affinity ligand for RA receptor...
19.
Nayak A, Deshpande D, Shah S, Villalba D, Yi R, Wang N, et al.
Am J Physiol Lung Cell Mol Physiol
. 2021 Oct;
321(6):L1044-L1054.
PMID: 34668419
The proton-sensing receptor, ovarian cancer G protein-coupled receptor (OGR1), has been shown to be expressed in airway smooth muscle (ASM) cells and is capable of promoting ASM contraction in response...
20.
Sharma P, Yadav S, Shah S, Javed E, Lim J, Pan S, et al.
Am J Respir Cell Mol Biol
. 2021 Jul;
65(6):658-671.
PMID: 34293268
Exaggerated airway smooth muscle (ASM) contraction regulated by the Gq family of G protein-coupled receptors causes airway hyperresponsiveness in asthma. Activation of Gq-coupled G protein-coupled receptors leads to phospholipase C...