Deepa Waghray
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Explore the profile of Deepa Waghray including associated specialties, affiliations and a list of published articles.
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13
Citations
989
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Recent Articles
1.
Jiang H, Limsuwannarot S, Kulhanek K, Pal A, Rysavy L, Su L, et al.
bioRxiv
. 2025 Jan;
PMID: 39868284
Arming T cells with a synthetically orthogonal IL-9 receptor (o9R) permits facile engraftment and potent anti-tumor functions. We considered whether the paucity of natural IL-9R expression could be exploited for...
2.
Wang N, Waghray D, Caveney N, Jude K, Garcia K
Proc Natl Acad Sci U S A
. 2024 Apr;
121(19):e2403031121.
PMID: 38687785
The loading of processed peptides on to major histocompatibility complex II (MHC-II) molecules for recognition by T cells is vital to cell-mediated adaptive immunity. As part of this process, MHC-II...
3.
Tsutsumi N, Hwang S, Waghray D, Hansen S, Jude K, Wang N, et al.
Proc Natl Acad Sci U S A
. 2023 Mar;
120(11):e2218238120.
PMID: 36893265
Wnt morphogens are critical for embryonic development and tissue regeneration. Canonical Wnts form ternary receptor complexes composed of tissue-specific Frizzled (Fzd) receptors together with the shared LRP5/6 coreceptors to initiate...
4.
Caveney N, Saxton R, Waghray D, Glassman C, Tsutsumi N, Hubbard S, et al.
Cell Rep
. 2023 Mar;
42(3):112201.
PMID: 36867534
Janus kinases (JAKs) mediate signal transduction downstream of cytokine receptors. Cytokine-dependent dimerization is conveyed across the cell membrane to drive JAK dimerization, trans-phosphorylation, and activation. Activated JAKs in turn phosphorylate...
5.
Tsutsumi N, Maeda S, Qu Q, Vogele M, Jude K, Suomivuori C, et al.
Sci Adv
. 2022 Jan;
8(3):eabl5442.
PMID: 35061538
Human cytomegalovirus (HCMV) encodes G protein-coupled receptors (GPCRs) and , which facilitate viral pathogenesis through engagement of host G proteins. Here we report cryo-electron microscopy structures of US28 and US27...
6.
Tsutsumi N, Qu Q, Mavri M, Baggesen M, Maeda S, Waghray D, et al.
Immunity
. 2021 Jul;
54(7):1405-1416.e7.
PMID: 34216564
Epstein-Barr virus (EBV) encodes a G protein-coupled receptor (GPCR) termed BILF1 that is essential for EBV-mediated immunosuppression and oncogenesis. BILF1 couples with inhibitory G protein (Gi), the major intracellular signaling...
7.
Tsutsumi N, Mukherjee S, Waghray D, Janda C, Jude K, Miao Y, et al.
Elife
. 2020 Aug;
9.
PMID: 32762848
Frizzleds (Fzd) are the primary receptors for Wnt morphogens, which are essential regulators of stem cell biology, yet the structural basis of Wnt signaling through Fzd remains poorly understood. Here...
8.
Miles T, Spiess K, Jude K, Tsutsumi N, Burg J, Ingram J, et al.
Elife
. 2018 Jun;
7.
PMID: 29882741
Human cytomegalovirus has hijacked and evolved a human G-protein-coupled receptor into US28, which functions as a promiscuous chemokine 'sink' to facilitate evasion of host immune responses. To probe the molecular...
9.
Burg J, Ingram J, Venkatakrishnan A, Jude K, Dukkipati A, Feinberg E, et al.
Science
. 2015 Mar;
347(6226):1113-7.
PMID: 25745166
Chemokines are small proteins that function as immune modulators through activation of chemokine G protein-coupled receptors (GPCRs). Several viruses also encode chemokines and chemokine receptors to subvert the host immune...
10.
Birnbaum M, Berry R, Hsiao Y, Chen Z, Shingu-Vazquez M, Yu X, et al.
Proc Natl Acad Sci U S A
. 2014 Nov;
111(49):17576-81.
PMID: 25422432
αβ T-cell receptor (TCR) activation plays a crucial role for T-cell function. However, the TCR itself does not possess signaling domains. Instead, the TCR is noncovalently coupled to a conserved...