Claudia Y Janda
Overview
Explore the profile of Claudia Y Janda including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
1294
Followers
0
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Recent Articles
1.
Wijnakker J, van Son G, Krueger D, van de Wetering W, Lopez-Iglesias C, Schreurs R, et al.
Proc Natl Acad Sci U S A
. 2025 Jan;
122(1):e2420595121.
PMID: 39793062
Matrigel/BME, a basement membrane-like preparation, supports long-term growth of epithelial 3D organoids from adult stem cells [T. Sato , , 262-265 (2009); T. Sato , , 1762-1772 (2011)]. Here, we...
2.
Janssen F, Lak N, Janda C, Kester L, Meister M, Merks J, et al.
NPJ Precis Oncol
. 2024 Sep;
8(1):210.
PMID: 39322659
No abstract available.
3.
Janssen F, Lak N, Janda C, Kester L, Meister M, Merks J, et al.
NPJ Precis Oncol
. 2024 Aug;
8(1):172.
PMID: 39097671
Liquid biopsies are emerging as an alternative source for pediatric cancer biomarkers with potential applications during all stages of patient care, from diagnosis to long-term follow-up. While developments within this...
4.
Tsutsumi N, Hwang S, Waghray D, Hansen S, Jude K, Wang N, et al.
Proc Natl Acad Sci U S A
. 2023 Mar;
120(11):e2218238120.
PMID: 36893265
Wnt morphogens are critical for embryonic development and tissue regeneration. Canonical Wnts form ternary receptor complexes composed of tissue-specific Frizzled (Fzd) receptors together with the shared LRP5/6 coreceptors to initiate...
5.
Sonnen K, Janda C
Biochem J
. 2021 Dec;
478(23):4045-4070.
PMID: 34871368
In multicellular organisms, cellular behaviour is tightly regulated to allow proper embryonic development and maintenance of adult tissue. A critical component in this control is the communication between cells via...
6.
Fowler T, Mitchell T, Janda C, Xie L, Tu S, Chen H, et al.
Nat Commun
. 2021 Jun;
12(1):3247.
PMID: 34059688
The Wnt signaling pathway is intricately connected with bone mass regulation in humans and rodent models. We designed an antibody-based platform that generates potent and selective Wnt mimetics. Using this...
7.
Miao Y, Ha A, de Lau W, Yuki K, Santos A, You C, et al.
Cell Stem Cell
. 2020 Aug;
27(5):840-851.e6.
PMID: 32818433
Modulation of Wnt signaling has untapped potential in regenerative medicine due to its essential functions in stem cell homeostasis. However, Wnt lipidation and Wnt-Frizzled (Fzd) cross-reactivity have hindered translational Wnt...
8.
Tsutsumi N, Mukherjee S, Waghray D, Janda C, Jude K, Miao Y, et al.
Elife
. 2020 Aug;
9.
PMID: 32762848
Frizzleds (Fzd) are the primary receptors for Wnt morphogens, which are essential regulators of stem cell biology, yet the structural basis of Wnt signaling through Fzd remains poorly understood. Here...
9.
Dang L, Miao Y, Ha A, Yuki K, Park K, Janda C, et al.
Nat Struct Mol Biol
. 2019 May;
26(6):407-414.
PMID: 31086346
To discriminate between closely related members of a protein family that differ at a limited number of spatially distant positions is a challenge for drug discovery. We describe a combined...
10.
Yan K, Janda C, Chang J, Zheng G, Larkin K, Luca V, et al.
Nature
. 2017 May;
545(7653):238-242.
PMID: 28467820
The canonical Wnt/β-catenin signalling pathway governs diverse developmental, homeostatic and pathological processes. Palmitoylated Wnt ligands engage cell-surface frizzled (FZD) receptors and LRP5 and LRP6 co-receptors, enabling β-catenin nuclear translocation and...