Naotaka Tsutsumi
Overview
Explore the profile of Naotaka Tsutsumi including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
515
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Recent Articles
1.
Tsutsumi N, Kildedal D, Hansen O, Kong Q, Schols D, Loy T, et al.
Br J Pharmacol
. 2024 Oct;
182(1):26-51.
PMID: 39443818
G protein-coupled receptors (GPCRs) are pivotal in cellular signalling and drug targeting. Herpesviruses encode GPCRs (vGPCRs) to manipulate cellular signalling, thereby regulating various aspects of the virus life cycle, such...
2.
Jaunet-Lahary T, Shimamura T, Hayashi M, Nomura N, Hirasawa K, Shimizu T, et al.
Nat Commun
. 2023 Sep;
14(1):6053.
PMID: 37770479
No abstract available.
3.
Tsutsumi N, Masoumi Z, James S, Tucker J, Winkelmann H, Grey W, et al.
Cell
. 2023 Aug;
186(19):4189-4203.e22.
PMID: 37633268
Thrombopoietin (THPO or TPO) is an essential cytokine for hematopoietic stem cell (HSC) maintenance and megakaryocyte differentiation. Here, we report the 3.4 Å resolution cryoelectron microscopy structure of the extracellular...
4.
Structural insight into guanylyl cyclase receptor hijacking of the kinase-Hsp90 regulatory mechanism
Caveney N, Tsutsumi N, Garcia K
Elife
. 2023 Aug;
12.
PMID: 37535399
Membrane receptor guanylyl cyclases play a role in many important facets of human physiology, from regulating blood pressure to intestinal fluid secretion. The structural mechanisms which influence these important physiological...
5.
Jaunet-Lahary T, Shimamura T, Hayashi M, Nomura N, Hirasawa K, Shimizu T, et al.
Nat Commun
. 2023 Apr;
14(1):1730.
PMID: 37012268
An oxalate-degrading bacterium in the gut microbiota absorbs food-derived oxalate to use this as a carbon and energy source, thereby reducing the risk of kidney stone formation in host animals....
6.
Tsutsumi N, Hwang S, Waghray D, Hansen S, Jude K, Wang N, et al.
Proc Natl Acad Sci U S A
. 2023 Mar;
120(11):e2218238120.
PMID: 36893265
Wnt morphogens are critical for embryonic development and tissue regeneration. Canonical Wnts form ternary receptor complexes composed of tissue-specific Frizzled (Fzd) receptors together with the shared LRP5/6 coreceptors to initiate...
7.
Caveney N, Saxton R, Waghray D, Glassman C, Tsutsumi N, Hubbard S, et al.
Cell Rep
. 2023 Mar;
42(3):112201.
PMID: 36867534
Janus kinases (JAKs) mediate signal transduction downstream of cytokine receptors. Cytokine-dependent dimerization is conveyed across the cell membrane to drive JAK dimerization, trans-phosphorylation, and activation. Activated JAKs in turn phosphorylate...
8.
Structural insight into guanylyl cyclase receptor hijacking of the kinase-Hsp90 regulatory mechanism
Caveney N, Tsutsumi N, Garcia K
bioRxiv
. 2023 Feb;
PMID: 36824799
Membrane receptor guanylyl cyclases play a role in many important facets of human physiology, from regulating blood pressure to intestinal fluid secretion. The structural mechanisms which influence these important physiological...
9.
Wilson S, Caveney N, Yen M, Pollmann C, Xiang X, Jude K, et al.
Nature
. 2022 Jul;
609(7927):622-629.
PMID: 35863378
The IL-17 family of cytokines and receptors have central roles in host defence against infection and development of inflammatory diseases. The compositions and structures of functional IL-17 family ligand-receptor signalling...
10.
Rosenkilde M, Tsutsumi N, Knerr J, Kildedal D, Garcia K
Annu Rev Virol
. 2022 Jun;
9(1):329-351.
PMID: 35671566
Herpesviruses are ancient large DNA viruses that have exploited gene capture as part of their strategy to escape immune surveillance, promote virus spreading, or reprogram host cells to benefit their...