Deepa Balasubramaniam
Overview
Explore the profile of Deepa Balasubramaniam including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
390
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Recent Articles
1.
Chen Y, Yang Y, Zhen E, Beyer T, Li H, Wen Y, et al.
Proc Natl Acad Sci U S A
. 2024 Apr;
121(17):e2322332121.
PMID: 38625948
Apolipoprotein AV (APOA5) lowers plasma triglyceride (TG) levels by binding to the angiopoietin-like protein 3/8 complex (ANGPTL3/8) and suppressing its capacity to inhibit lipoprotein lipase (LPL) catalytic activity and its...
2.
OLeary T, Balasubramaniam D, Hughes K, Foster D, Boyles J, Coleman K, et al.
Anal Chem
. 2023 Jun;
95(27):10204-10210.
PMID: 37379434
Hydrogen-deuterium exchange coupled with mass spectrometry (HDX-MS) is widely used for monoclonal antibody (mAb) epitope mapping, which aids in the development of therapeutic mAbs and vaccines, as well as enables...
3.
Balasubramaniam D, Schroeder O, Russell A, Fitchett J, Austin A, Beyer T, et al.
J Lipid Res
. 2022 Mar;
63(5):100198.
PMID: 35307397
Triglycerides (TG) are required for fatty acid transport and storage and are essential for human health. Angiopoietin-like-protein 8 (ANGPTL8) has previously been shown to form a complex with ANGPTL3 that...
4.
Jones B, Brown-Augsburger P, Corbett K, Westendorf K, Davies J, Cujec T, et al.
Sci Transl Med
. 2021 Apr;
13(593).
PMID: 33820835
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) poses a public health threat for which preventive and therapeutic agents are urgently needed. Neutralizing antibodies are a key class of therapeutics that may...
5.
Jones B, Brown-Augsburger P, Corbett K, Westendorf K, Davies J, Cujec T, et al.
bioRxiv
. 2020 Oct;
PMID: 33024963
One Sentence Summary: LY-CoV555, an anti-spike antibody derived from a convalescent COVID-19 patient, potently neutralizes SARS-CoV-2 and protects the upper and lower airways of non-human primates against SARS-CoV-2 infection.
6.
Froning K, Maguire J, Sereno A, Huang F, Chang S, Weichert K, et al.
Nat Commun
. 2020 May;
11(1):2330.
PMID: 32393818
Recombinant T cell receptors (TCRs) can be used to redirect naïve T cells to eliminate virally infected or cancerous cells; however, they are plagued by low stability and uneven expression....
7.
Datta-Mannan A, Brown R, Fitchett J, Heng A, Balasubramaniam D, Pereira J, et al.
Biochemistry
. 2019 Jun;
58(28):3116-3132.
PMID: 31241304
Interest in the development of bi- or multispecific antibody (BsAbs)-based biotherapeutics is growing rapidly due to their inherent ability to interact with many targets simultaneously, thereby potentially protracting their functionality...
8.
Ramirez-Sarmiento C, Baez M, Zamora R, Balasubramaniam D, Babul J, Komives E, et al.
Biophys J
. 2015 May;
108(9):2350-61.
PMID: 25954892
Escherichia coli phosphofructokinase-2 (Pfk-2) is an obligate homodimer that follows a highly cooperative three-state folding mechanism N2 ↔ 2I ↔ 2U. The strong coupling between dissociation and unfolding is a...
9.
Balasubramaniam D, Schiffer J, Parnell J, Mir S, Amaro R, Komives E
Biochemistry
. 2015 Feb;
54(8):1673-80.
PMID: 25654263
The ankyrin repeat and SOCS box (ASB) family is composed of 18 proteins and belongs to the suppressor of cytokine signaling (SOCS) box protein superfamily. The ASB proteins function as...
10.
Balasubramaniam D, Komives E
Structure
. 2014 Apr;
22(4):511-2.
PMID: 24717558
Using HXMS to measure protein dynamics, Fang and colleagues (in this issue of Structure) probe the dynamics of processivity clamp proteins from all kingdoms of life. The proteins have similar...