Dayne L Filer
Overview
Explore the profile of Dayne L Filer including associated specialties, affiliations and a list of published articles.
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14
Citations
400
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Recent Articles
1.
Bost D, Bizon C, Tilson J, Filer D, Gizer I, Wilhelmsen K
Complex Psychiatry
. 2022 Nov;
8(1-2):35-46.
PMID: 36407771
Introduction: Genome-wide association studies (GWAS) have played a critical role in identifying many thousands of loci associated with complex phenotypes and diseases. This has led to several translations of novel...
2.
Filer D, Hoffman K, Sargis R, Trasande L, Kassotis C
Environ Health Perspect
. 2022 May;
130(5):57005.
PMID: 35533074
Background: Research suggests environmental contaminants can impact metabolic health; however, high costs prohibit screening of putative metabolic disruptors. High-throughput screening programs, such as ToxCast, hold promise to reduce testing gaps...
3.
Jeffries C, Ford J, Tilson J, Perkins D, Bost D, Filer D, et al.
Sci Rep
. 2022 Apr;
12(1):5440.
PMID: 35361850
Regularized regression analysis is a mature analytic approach to identify weighted sums of variables predicting outcomes. We present a novel Coarse Approximation Linear Function (CALF) to frugally select important predictors...
4.
Filer D, Kuo F, Brandt A, Tilley C, Mieczkowski P, Berg J, et al.
BMC Bioinformatics
. 2021 Jul;
22(1):374.
PMID: 34284719
Background: As exome sequencing (ES) integrates into clinical practice, we should make every effort to utilize all information generated. Copy-number variation can lead to Mendelian disorders, but small copy-number variants...
5.
Filer D, Mieczkowski P, Brandt A, Gilmore K, Powell B, Berg J, et al.
Prenat Diagn
. 2021 Jul;
42(5):567-573.
PMID: 34265090
Objective: Sequencing cell-free DNA now allows detection of large chromosomal abnormalities and dominant Mendelian disorders in the prenatal period. Improving upon these methods would allow newborn screening programs to begin...
6.
Aliverti E, Tilson J, Filer D, Babcock B, Colaneri A, Ocasio J, et al.
Bioinformatics
. 2020 Mar;
36(11):3522-3527.
PMID: 32176244
Motivation: Low-dimensional representations of high-dimensional data are routinely employed in biomedical research to visualize, interpret and communicate results from different pipelines. In this article, we propose a novel procedure to...
7.
Morgan A, Brazeau N, Ngasala B, Mhamilawa L, Denton M, Msellem M, et al.
Malar J
. 2020 Jan;
19(1):47.
PMID: 31992305
Background: Tanzania's Zanzibar archipelago has made significant gains in malaria control over the last decade and is a target for malaria elimination. Despite consistent implementation of effective tools since 2002,...
8.
Karmaus A, Trautman T, Krishan M, Filer D, Fix L
Food Chem Toxicol
. 2017 Mar;
103:174-182.
PMID: 28285935
High-throughput in vitro assays and exposure prediction efforts are paving the way for modeling chemical risk; however, the utility of such extensive datasets can be limited or misleading when annotation...
9.
Filer D, Kothiya P, Setzer R, Judson R, Martin M
Bioinformatics
. 2016 Nov;
33(4):618-620.
PMID: 27797781
Motivation: Large high-throughput screening (HTS) efforts are widely used in drug development and chemical toxicity screening. Wide use and integration of these data can benefit from an efficient, transparent and...
10.
Karmaus A, Filer D, Martin M, Houck K
Food Chem Toxicol
. 2016 Apr;
92:188-96.
PMID: 27103583
Thousands of chemicals are directly added to or come in contact with food, many of which have undergone little to no toxicological evaluation. The landscape of the food-relevant chemical universe...