David W Woessner
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Explore the profile of David W Woessner including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
253
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0
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Recent Articles
1.
Miller G, Woessner D, Sirch M, Lim C
Mol Pharm
. 2013 Aug;
10(9):3475-83.
PMID: 23915432
The oncoprotein Bcr-Abl, the causative agent of chronic myeloid leukemia (CML), requires homo-oligomerization via a coiled-coil domain to function [Bartram, C. R.; et al. Nature 1983, 306 (5940), 277-280; and...
2.
Woessner D, Lim C
Mol Pharm
. 2012 Dec;
10(1):270-7.
PMID: 23211037
Chronic myeloid leukemia (CML) is a myeloproliferative disorder caused by expression of the fusion gene BCR-ABL following a chromosomal translocation in the hematopoietic stem cell. Therapeutic management of CML uses...
3.
Constance J, Woessner D, Matissek K, Mossalam M, Lim C
Mol Pharm
. 2012 Sep;
9(11):3318-29.
PMID: 22957899
The oncoprotein Bcr-Abl stimulates prosurvival pathways and suppresses apoptosis from its exclusively cytoplasmic locale, but when targeted to the mitochondrial compartment of leukemia cells, Bcr-Abl was potently cytotoxic. Therefore, we...
4.
Dixon A, Miller G, Bruno B, Constance J, Woessner D, Fidler T, et al.
Mol Pharm
. 2012 Mar;
9(5):1535.
PMID: 22444272
No abstract available.
5.
Woessner D, Lim C, Deininger M
Cancer J
. 2011 Dec;
17(6):477-86.
PMID: 22157291
Targeted small-molecule drugs have revolutionized treatment of chronic myeloid leukemia (CML) during the last decade. These agents interrupt a constitutively active BCR-ABL, the causative agent for CML, by interfering with...
6.
Dixon A, Miller G, Bruno B, Constance J, Woessner D, Fidler T, et al.
Mol Pharm
. 2011 Dec;
9(1):187-95.
PMID: 22136227
The oncoprotein Bcr-Abl drives aberrant downstream activity through trans-autophosphorylation of homo-oligomers in chronic myelogenous leukemia (CML).(1, 2) The formation of Bcr-Abl oligomers is achieved through the coiled-coil domain at the...
7.
Dixon A, Pendley S, Bruno B, Woessner D, Shimpi A, Cheatham 3rd T, et al.
J Biol Chem
. 2011 Jun;
286(31):27751-60.
PMID: 21659527
Oligomerization is an important regulatory mechanism for many proteins, including oncoproteins and other pathogenic proteins. The oncoprotein Bcr-Abl relies on oligomerization via its coiled coil domain for its kinase activity,...
8.
Brigande J, Gubbels S, Woessner D, Jungwirth J, Bresee C
Methods Mol Biol
. 2008 Oct;
493:125-39.
PMID: 18839345
The mammalian inner ear forms from a thickened patch of head ectoderm called the otic placode. The placodal ectoderm invaginates to form a cup whose edges cinch together to establish...
9.
Gubbels S, Woessner D, Mitchell J, Ricci A, Brigande J
Nature
. 2008 Aug;
455(7212):537-41.
PMID: 18754012
Sensory hair cells in the mammalian cochlea convert mechanical stimuli into electrical impulses that subserve audition. Loss of hair cells and their innervating neurons is the most frequent cause of...